Marine Compounds and Cancer 2020

Edited by
June 2021
480 pages
  • ISBN978-3-0365-0630-2 (Hardback)
  • ISBN978-3-0365-0631-9 (PDF)

This book is a reprint of the Special Issue Marine Compounds and Cancer that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
apoptosis; fucoidan; hepatocellular carcinoma; reactive oxygen species; 3-alkylpyridinium polymers; apoptosis; nicotine; nicotinic acetylcholine receptor; non-small cell lung carcinoma; melanoma; sinulariolide; proteomic; mitochondria; apoptosis; caspase cascade; marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity; apoptosis; dibromotyrosine; mitochondrial dysfunction; oxidative stress; topoisomerase; epigonal organ; bonnethead shark; Jurkat; apoptosis; tumor cell line; hippuristanol; PEL; AP-1; STAT3; Akt; colorectal cancer; apoptosis; marine mollusc; brominated indoles; shrimp; chemoprevention; fatty acids; carotenoids; cancer; fucoidan; nanoparticle; osteosarcoma; apoptosis; lung metastasis; elisidepsin; lipid rafts; hydroxylated lipids; fatty acid 2-hydroxylase; cooperative binding; membrane permeabilization; marine organisms; polysaccharides; anticancer; chemoprevention; anticarcinogenic; mechanisms of action; fumigaclavine C; apoptosis; anti-proliferation; mitochondrial pathway; anti-cancer; anti-proliferative; apoptosis; carotenoid; cell cycle arrest; fucoxanthin; apoptosis; azoxymethane; bioactive natural product; colorectal cancer; isatin; in vivo model; marine mollusc; Marthasterias glacialis L.; palmitic acid; ER-stress; CHOP; apoptosis; Antibody Drug Conjugates (ADCs); marine antitumor agents; clinical trials; approved antitumor agents; AD0157; angiogenesis; cancer; apoptosis; marine drug; pyrrolidinedione; marine organisms; secondary metabolites; cancer preventive; chemopreventive; anticarcinogenic; mechanisms of action; trabectedin; plitidepsin; tumor-associated macrophages; tumor microenvironment; fucoidan; anticancer; preclinical; anticancer immunity; antiangiogenesis; fascaplysin; cyclin-dependent kinase; small cell lung cancer; cytotoxicity; reactive oxygen species; camptothecin; poly(ADP-ribose)-polymerase inhibitor; breast cancer; colorectal cancer; seaweed; therapeutic compounds; reactive oxygen species; autophagy; marine drugs; autophagy inhibitors; autophagy inducers; macrolide; apoptosis; programmed cell death; mitochondria; cytotoxicity; energy stress; araguspongine C; autophagy; breast cancer; c-Met; HER2; gemcitabine; pazopanib; phase I; safety; soft tissue sarcoma; trabectedin; pachastrissamine; jaspine B; carbocyclic analogue; cytotoxicity; sphingosine kinase inhibitor; molecular modeling; trabectedin; ET-743; DNA minor groove binder; soft tissue sarcoma; chemotherapy; bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM); anti-metastatic activity; cell adhesion; β1-integrin; FAK; BEL-7402 cell; triterpene glycosides; sea cucumbers; antitumor activities; apoptosis; arrest of cell cycle; cytotoxicity; antibacterial; marangucyclines; deep-sea; Streptomyces sp. SCSIO 11594; LS-1; SNU-C5/5-FU; apoptosis; TGF-β signaling; carcinoembryonic antigen; kalkitoxin; breast cancer; Moorea producens; mitochondria toxin; VEGF; angiogenesis inhibitor; hypoxia-inducible factor-1; HIF-1; Lyngbya majuscula; marine metabolites; SZ-685C; nonfunctioning pituitary adenomas; apoptosis; Ecklonia cava; phlorotannins; dieckol; breast cancer; migration; sipholenol A; ABC transporter; multidrug resistance; P-gp/ABCB1; BCRP/ABCG2; MRP1/ABCC1; marine natural products; glioblastoma; xyloketal B; proliferation; migration; TRPM7; marine compound; ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera; n/a; Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling; Caribbean sponge; plakortide; endoperoxide; leukemia; multi-drug resistant leukemia; cytotoxicity; Sarcophyton ehrenbergi; soft coral; terpenes; cembranoids; cytotoxic activity; molecular docking; fucoidan; uveal melanoma; VEGF; angiogenesis; oxidative stress; virtual screening; molecular docking; Topo I inhibitor; low toxic; natural product; Ulva fasciata; selenium-containing polysaccharide-protein complex; apoptosis; mitochondria; reactive oxygen species; pseudopterosin; NF-κB; p65; inflammation; tumor microenvironment; breast cancer; cytokine release; IL-6; TNFα; MCP-1; glucocorticoid receptor; paulomycins; Micromonospora; antitumor; Cantabrian Sea-derived actinobacteria; puupehenones; sponges; marine drugs; antiangiogenic; antitumoral; porifera/sponge; evolution; cancer; cancer genes; molecular oncology; n/a; bromophenol; molecular mechanisms; apoptosis; cell cycle; PI3K/Akt; p38/ERK; ROS; human lung cancer; marine mollusc; glycosaminoglycans; antiproliferative; anticancer; heparan sulphate; gliotoxin; NSCLC; adriamycin resistance; apoptosis; Sepia ink polysaccharides; chemoprevention; antitumour; chemosensitization; anticoagulation; sea anemone; drug discovery; cancer; antiangiogenic; endothelial cells; RGD motif; kunitz type inhibitor; prostate cancer; antioxidant; anti-proliferative; apoptosis; natural marine compounds; marine biotechnology; microalgae; anti-cancer; marine sponges; Aeroplysinin; Isofistularin; pheochromocytoma and paraganglioma; metastasis; cancer progression; cell adhesion molecules; integrin β1; hypoxia; phycocyanin; non-small cell lung cancer; proliferation; apoptosis; NF-κB signaling; marine-derived drugs; cancer; bioanalysis; chromatography; manzamine A; cell cycle; apoptosis; epithelial–mesenchymal transition; colorectal cancer; fascaplysin; lung cancer; circulating tumor cells; signal transduction; cytotoxicity; cisplatin; Lampetra morii; buccal gland; cystatin F; anti-angiogenesis; cystatin superfamily; Antimicrobial peptide (AMP); Tilapia piscidin 4 (TP4); non-small cell lung cancer (NSCLC); itampolin A; FBDD; antitumor; p38α; novel inhibitor; tetracenomycin X; cell cycle arrest; cyclin D1; proteasomal degradation; p38; c-JUN; λ-carrageenan; heparanase; anticoagulant; depolymerisation; cell migration; Aspergillus; naphthopyrones; cytotoxicity; endophytic fungus; Leathesia nana; mangrove-derived actinomycete; ansamycins; divergolides; apoptosis-inducing activity; breast cancer; actinomycin; EMT; migration; invasion; fucoidan; low molecular weight fucoidan extract; N-Ras; neuroblastoma-rat sarcoma; Cancer; programmed cell death-ligand 1; programmed cell death-ligand 2; human sarcoma cell line (HT1080 cells); human normal diploid fibroblast (TIG-1 cells); chimera; chemical conjugation; marine natural products; anticancer agent; hybridization; n/a; α9-nicotinic acetylcholine receptors (nAChRs); breast cancer cells; αO-conotoxin GeXIVA; apoptosis; anti-proliferation; targeted therapy; gorgonian; Leptogorgia; humulane sesquiterpenoids; anticancer activity; 12-deacetyl-12-epi-scalaradial; HeLa cells; apoptosis; Nur77; MAPK/ERK pathway; Mycalin A; C15 acetogenins; synthetic analogues; antiproliferative activity; A375 and HeLa cell lines; polyoxygenated steroids; sponge; Haliclona gracilis; anticancer activity; Thalassia testudinum; thalassiolin B; polyphenols; CYP1A1; benzo[a]pyrene; chemoprevention; fascaplysin; prostate cancer; JNK1/2; natural products; synergism; n/a; A549 cells; cancer; cytoskeleton; phlorotannins; P2X7 receptor; pollution; Thalassia testudinum; cytotoxicity; antitumor; anti-angiogenic; gene expression; HSP90; inhibitor; EMT; metastasis; breast cancer

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