The Tight Junction and Its Proteins

More Than Just a Barrier

Edited by
November 2020
432 pages
  • ISBN978-3-03943-300-1 (Hardback)
  • ISBN978-3-03943-301-8 (PDF)

This book is a reprint of the Special Issue The Tight Junction and Its Proteins: More Than Just a Barrier that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
  • Hardback
© 2021 by the authors; CC BY license
tissue barrier; tight junction; claudins; tricellulin; tight junctions; organ preservation; intestine; transplantation; ischemia; intestinal mucosa; lung; epithelia; interleukin 13; tight junction; UBE2Z; ubiquitin; tight junction; osmolality; hydrostatic pressure; cancer; sensor; tricellular tight junctions; endometrial cancer; epithelial barrier dysfunction; Claudin-7; tight junctions; permeability; WNK4; epithelial sodium channel (ENaC), collecting duct cells; claudin-1; hydrogen peroxide; phosphorylation; tight junction; claudin; angulin; drug development; angubindin-1; Clostridium perfringens enterotoxin; Clostridium perfringens iota-toxin; antibody; Mz-ChA-1 cells; biliary epithelial cells; phosphatidylcholine; mucus; tight junctions; paracellular transport; atopic dermatitis; tight junctions; cytokines; claudin; STAT3; tight junctions; ZO-2; cholestasis; gene transcription; hypertrophy; tumor suppressor; NLS; NES; CaSR; RhoA; barrier function; paracellular permeability; antidiuretic hormone; tight junction; Claudin-14; CLDN14; hearing loss; vestibular function; cochlear implantation; Clostridium perfringens enterotoxin; claudin-1; Hepatitis C Virus; viral entry; epidermal barrier; reconstructed human epidermis; claudin targeting; Campylobacter jejuni; curcumin; tight junction; claudin; apoptosis; co-culture; mouse colon; cytokines; TNF; NFκB; tight junction; tricellulin; lipolysis-stimulated lipoprotein receptor (LSR); angulin; epithelial barrier; cell–cell contact; apoptosis; caspase; tight junctions; claudins; kidney stones; paracellular transport; ion reabsorption; quercetin; brain barriers; blood-brain barrier; neurovascular unit; blood-cerebrospinal fluid barrier; arachnoid barrier; glia limitans; tight junctions; adherens junctions; tight junction; paracellular permeability; paracellular sodium transport; thick ascending limb; nephropathy; HELIX syndrome; hypokalemia; hypermagnesemia; anhidrosis; gland dysfunction; aging; blood–brain barrier; tight junction; tight junction; claudin; mutations; kidney; liver; skin; human; mice; disease; claudin; tight junctions; blood–brain barrier; in silico; drug discovery; membrane proteins; protein interactions; molecular dynamics; antibiotic-associated hemorrhagic colitis; tight junction; claudin; apoptosis; Klebsiella oxytoca; barrier function; tight junction assembly; monocytes; celiac disease; claudin-2; tight junctions; epithelium; cancer; inflammation; fibrosis; paracellular permeability; proliferation; migration; tricellulin; tricellular tight junction; paracellular water transport; tight epithelium; MDCK C7 cells; tight junctions; cell growth; epithelia; endothelia; proliferation; migration; tight junction; adherens junction; apical junctional complex; AMP-activated protein kinase (AMPK); paracellular barrier; tight junction; protein structure; protein domain; claudins; occludin; tricellulin; junctional adhesion molecule; zonula occludens; MAGUK proteins; PDZ domain; claudins; cancer; stem cell; chemoresistance; retinal pigment epithelium; retinopathy; tight junction; epithelial barrier; barrier formation; collecting duct; tight junction; claudin; tight junction; claudin-5; neuropathic pain; nerve injury; dorsal root ganglion; enteropathogenic E. coli (EPEC); tight junctions (TJ); polarity; atypical aPKCζ; transepithelial electrical resistance (TER); sorting nexin 9 (SNX9); EspF; claudin 1; tight junctions; tumor; metastasis; epithelial to mesenchymal transition; cerebral cavernous malformation; endothelial barrier; epithelial barrier; Rho; ROCK; MEKK3; claudin; molecular dynamics; tight junction; ion transport; ion channel; super-resolution microscopy; structured illumination microscopy; stimulated emission depletion; single molecule localization microscopy; adherens junction; tight junction; Claudin; occludin; blood-biliary barrier; chronic liver disease; hepatocellular carcinoma; cholangiocellular carcinoma; NISCH syndrome; barrier function; tight junction; repair; occludin; claudin; NHE2; ClC-2; tight junction; barrier function; inflammatory bowel disease; drug development; mucosal immunology; cytokines; ZO-1; occludin; claudin; actomyosin; aquaporin; claudin; drinking rate; epithelial fluid transport; enterocyte; occludin; osmoregulation; paracellular; proximal tubule; calcium permeability; claudin-12; tight junction; claudin; occludin; tricellulin; angulin; paracellular channels and barriers; cell polarity; pathogens; immune cells; environmental sensors; cancer