Organophosphorus Chemistry 2018

Edited by
March 2020
602 pages
  • ISBN978-3-03928-236-4 (Paperback)
  • ISBN978-3-03928-237-1 (PDF)

This book is a reprint of the Special Issue Organophosphorus Chemistry 2018 that was published in

Chemistry & Materials Science
Medicine & Pharmacology
Organophosphorus chemistry is an important discipline within organic chemistry. Phosphorus compounds, such as phosphines, trialkyl phosphites, phosphine oxides (chalcogenides), phosphonates, phosphinates and >P(O)H species, etc., may be important starting materials or intermediates in syntheses. Let us mention the Wittig reaction and the related transformations, the Arbuzov- and the Pudovik reactions, the Kabachnik–Fields condensation, the Hirao reaction, the Mitsunobu reaction, etc. Other reactions, e.g., homogeneous catalytic transformations or C-C coupling reactions involve P-ligands in transition metal (Pt, Pd, etc.) complex catalysts. The synthesis of chiral organophosphorus compounds means a continuous challenge. Methods have been elaborated for the resolution of tertiary phosphine oxides and for stereoselective organophosphorus transformations. P-heterocyclic compounds, including aromatic and bridged derivatives, P-functionalized macrocycles, dendrimers and low coordinated P-fragments, are also of interest. An important segment of organophosphorus chemistry is the pool of biologically-active compounds that are searched and used as drugs, or as plant-protecting agents. The natural analogue of P-compounds may also be mentioned. Many new phosphine oxides, phosphinates, phosphonates and phosphoric esters have been described, which may find application on a broad scale. Phase transfer catalysis, ionic liquids and detergents also have connections to phosphorus chemistry. Green chemical aspects of organophosphorus chemistry (e.g., microwave-assisted syntheses, solvent-free accomplishments, optimizations, and atom-efficient syntheses) represent a dynamically developing field. Last, but not least, theoretical approaches and computational chemistry are also a strong sub-discipline within organophosphorus chemistry.
  • Paperback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
amino acids; aminophosphonic acids; 1-aminoalkylphosphonic acids; 1-(acylamino)alkylphosphonic acids; 31P NMR spectra of intermediates; hydrolytic deacylation; synergy; 1,3-azaphospholes; Diels-Alder reaction; electrophilic substitution; DFT calculations; α-hydroxyphosphonate; Pudovik reaction; O-derivatization; oxidation; substitution; rearrangement; hydrolysis; dialkyl H-phosphonates; alcoholysis; transesterification; microwave; continuous flow reactor; organophosphorus chemistry; phosphonium salts; α-amidoalkylating agents; N-acyliminium cation; N-acylimine; diphosphines; electronic parameters; DFT; QTAIM; triple-decker; cyclo-P5; weakly coordinating; molybdenum; silver; copper; bis(phosphane) palladium complex; metallacycle; NORPHOS; allylic alkylation; asymmetric catalysis; chiral phosphines; C-H bond activation; polycyclic compounds; stereoselective synthesis; DFT calculations; phosphonic acids; aminophosphonic acids; phosphonocarboxylic acids; NMR-controlled titration; dissociation constants; stability constants; dynamic and specific NMR parameters; phosphorylation; dinucleotides; organophosphorus chemistry; mechanochemistry; dry eye syndrome; diquafosol; denufosol

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