Reprint
Amide Bond Activation
Edited by
July 2019
466 pages
- ISBN978-3-03921-203-3 (Paperback)
- ISBN978-3-03921-204-0 (PDF)
This book is a reprint of the Special Issue Amide Bond Activation that was published in
Chemistry & Materials Science
Medicine & Pharmacology
Summary
The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
Format
- Paperback
License
© 2019 by the authors; CC BY-NC-ND license
Keywords
fumardiamide; primaquine; succindiamide; Michael acceptor; biofilm eradication; antibacterial screening; antiviral activity; cytostatic activity; N,N-dimethylformamide; DMF; N,N-dimethylacetamide; DMAc; amination; amidation; thioamidation; formylation; carbonylation; cyanation; insertion; cyclization; amide; arynes; insertion; activation; heterocycles; organic synthesis; multi-component coupling reaction; aryl thioamides; thiourea; C-H/C-N activation; C-S formation; transition-metal-free; rotational barrier energy; amide bond; nuclear magnetic resonance; kinetic; density functional theory; non planar amide; base-catalyed hydrolysis; water solvation; entropy; transamidation; amide; amine; catalyst; catalysis; acylative cross-coupling; trialkylborane; amide activation; palladium; N-heterocyclic carbene; ruthenium (Ru); N-heterocyclic carbenes (NHCs); homogeneous catalysis; in situ; amide bonds; synthesis; density functional theory; cis/trans isomerization; secondary amides; dipeptides; steric effects; tert-butyl; additivity principle; amino acid transporters; amide bond; gemcitabine prodrug; metabolic stability; pancreatic cancer cells; pharmacokinetics; peptide bond cleavage; amide bond resonance; twisted amides; enzymes; metal complexes; catalysts; amide C–N bond activation; nickel catalysis; amidation; DFT study; reaction thermodynamics; amide resonance; anomeric effect; HERON reaction; pyramidal amides; physical organic chemistry; reaction mechanism; amide; activation; amidicity; carbonylicity; transamidation; acyl transfer; excited state; Suzuki-Miyaura; cross-coupling; aryl esters; C–O activation; Pd-catalysis; amides; carbanions; C–H acidity; nitro-aci tautomerism; molecular dynamics; density-functional theory; alkynes; C–H bond cleavage; C–N bond cleavage; cyclopentadienyl complexes; N-(1-naphthyl)acetamide; rhodium; [2+2+2] annulation; amide bond; sulfonamide bond; alkynes; addition reaction; aminoacylation; aminosulfonylation; pre-catalysts; palladium catalysis; amide bond activation; ester bond activation; cross-coupling; amide bond; bridged lactams; twisted amides; amides; Winkler-Dunitz parameters; N–C activation; hypersensitivity; nitrogen heterocycles; distortion; bridged sultams; amides; C-N σ bond cleavage; sodium; crown ether; amide hydrolysis; model compound; intramolecular catalysis; twisted amide; protease; intein; C-H functionalization; directing groups; amides; transition metals; catalysis