Interplay of Connexins and Pannexins in Tissue Function and Disease

Edited by
November 2018
380 pages
  • ISBN978-3-03897-392-8 (Paperback)
  • ISBN978-3-03897-393-5 (PDF)

This book is a reprint of the Special Issue Interplay of Connexins and Pannexins in Tissue Function and Disease that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology

This Special Issue is related to the 18th biannual International Gap Junction Conference (IGJC2017), which has been held at the Crowne Plaza Hotel, Glasgow and hosted by Glasgow Caledonian University, 29 July–3 August, 2017. This Special Issue, entitled “Interplay of Connexins and Pannexins in Tissue Function and Disease”, focuses on six key state-of-the-art reviews, written by leads in the field on cutting edge topics and the latest developments in clinical trials in diverse organ systems. A further 14 original articles contributed by delegates attending the meeting are also included and celebrate 50 years of Gap Junction Research.

Topics: Connexins and Pannexins:

  • Trafficking, Assembly, Gating, and Protein–Protein Interactions
  • Roles in the Cardiovascular System
  • Roles in Tumorigenesis
  • Roles in Epithelial Tissue and Wound Healing
  • Connexin Therapy Translated to Clinic
  • Paperback
© 2019 by the authors; CC BY license
atrial fibrillation; connexin; polymorphism; genetic variant; wound healing; connexin mimetic peptide; connexin hemichannel; cell migration; SiRNA; gap junctions; Connexin 43 (Cx43); breast cancer; survival analysis; intrinsic subtype; atrial fibrillation; gap junction channel; connexin40; Vj gating; patch clamp; irradiation; heart; connexin-43; miR-1; miR-21; atorvastatin; aspirin; connexins; gap junctions; transcription; translation; post-translational modifications; trafficking; Panx1; deafness; hearing; gap junction; inner ear; ABR; DPOAE; CM; epithelial tissue; connexin; pannexin; wound healing; inflammation; zebrafish models; gap junction; connexin; protein–protein interaction; intrinsically disordered protein; post-translational modification; intercalated disc; lymphatic endothelial cells; pannexins; Panx1; lymphangiogenesis; cell invasion; Vascular Endothelial Growth Factor-C (VEGF-C); Cx43; β-catenin; phosphorylation; cancer; connexin; growth control; invasion; metastasis; pannexin; therapeutics; casein kinase 1; phosphorylation; channel gating; gap junction permeability; arrhythmia; connexin; pannexin; vascular physiology; vascular disease; gap junctions; hemichannels; connexins; skin; wound healing; scar formation; peptide; pannexin; Panx1; Panx2; post-translational modification; traffic; N-glycosylation; channels; subcellular localization; pulmonary arterial hypertension (PAH); connexin43 (Cx43); gap junction; vascular reactivity; nitric oxide; serotonin; endothelin-1; isoprenaline; gap junction; cell-cell communication; connexin26; head and neck squamous cell carcinoma; ER-Golgi retention signal; cancer progression; connexin; connexin 26; GJB2 gene; deafness; protein-protein interaction; TJP1; CGN; FLNB; DAAM1; organ of Corti; oligomerization; concatenated connexins; gap junction; channel stoichiometry; heteromeric connexons; human connexin46; human connexin26; inside-out patch-clamp configuration; dual whole-cell patch-clamp; dye transfer; n/a