Reprint

Cell Lineage Choice During Haematopoiesis: A Commemorative Issue in Honor of Professor Antonius Rolink

Edited by
October 2018
166 pages
  • ISBN978-3-03897-274-7 (Paperback)
  • ISBN978-3-03897-275-4 (PDF)

This book is a reprint of the Special Issue Cell Lineage Choice During Haematopoiesis: A Commemorative Issue in Honor of Professor Antonius Rolink that was published in

Summary

This special issue of the International Journal of Molecular Sciences contains a collection of articles by colleagues of Antonius (Ton) Gerardus Rolink (19/04/1953-06/08/2017) and honors Ton’s life and profound knowledge of and huge contribution to science. Ton participated in an FP7 Marie Curie Initial Training Network called DECIDE, and partners have submitted articles for this Special Issue. Scientists outside this network have also submitted articles. The articles examine various aspects of how the hematopoietic stem-cell gives rise to the different types of blood and immune cells. These include decision-making by the hematopoietic stem cell and the importance of controlling events within cells and the niches the cell resides in. New insights into these processes at the basic scientific level have given rise to an emerging new model for the development of blood cells. In turn, changes to our understanding of this process have led to new and exciting propositions regarding what goes wrong during the early stages of the development of leukemia.

Format
  • Paperback
License
© 2018 by the authors; CC BY-NC-ND license
Keywords
ferritin heavy subunit; differentiation; K562; miR-150; GATA-1; leukemia; oncogenes; reprogramming; stem cells; cancer therapy; leukemia stem cell; mouse model; nuclear receptors; CCAAT-enhancer-binding proteins; CEBP genes; vitamin D receptor; retinoic acid receptor α; differentiation; acute myeloid leukemia; B-lymphocyte; development; transcription factors; lymphoid leukemia; cell differentiation; vitamin D; vitamin D receptor; vitamin D analogues; crystallography; blood and immune cells; cell lineage; cytokines; fate determination; hematopoiesis; stem cells; plasma cell; antibody; CLPTM1L; ITM2C; PLPP5; membrane protein; B lymphocyte development; metabolism; EFhd1; pre-BCR; mitochondria; mitoflash; oxidative phosphorylation; glycolysis; early hematopoiesis; B lymphopoiesis; bone marrow niches; stromal cells; interleukin-7; interleukin-7 receptor; B-cell development; signal transducer and activator of transcription 5; n/a