Reprint
Structure and Function of Antibodies
Edited by
February 2021
440 pages
- ISBN978-3-03943-897-6 (Hardback)
- ISBN978-3-03943-898-3 (PDF)
This book is a reprint of the Special Issue Structure and Function of Antibodies that was published in
Biology & Life Sciences
Summary
This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.
Format
- Hardback
License
© 2022 by the authors; CC BY-NC-ND license
Keywords
critical quality attributes; comparability; developability; glycosylation; quality target product profile; mass spectrometry; post-translational modifications; proteoforms; safety; Immunoglobulin E; FcεRI; CD23; allostery; cancer immunotherapy; AllergoOncology; IgE effector functions; monocytes; macrophages; ADCC; biopharmaceuticals; monoclonal antibodies; biosimilars; immunogencitity; B-cell tolerance; aggregates; anti-idiotypic; analytical electrophoresis; IgG subclasses; monoclonal IgG; protein charge; protein–protein interactions; ADC; antibody fragments; BiTE®; diabodies; domain antibodies; fab; ImmTAC®; Nanobody®; scFv; TandAb; V-NAR; IMGT; immunoinformatics; immunogenetics; IMGT-ONTOLOGY; IMGT Collier de Perles; IMGT unique numbering; immunoglobulin; antibody; paratope; complementarity determining region; Antibodies; IgG; Fc effector molecules; allotypes; glycosylation; Immunoglobulin G; Fc; conformational dynamics; molecular dynamics simulation; small-angle X-ray scattering; nuclear magnetic resonance; N-glycan; core fucosylation; chimeric antigen receptor; bispecific antibody; T-cell redirection; immune synapse; CD3ε, T cells; NK cells; tumor cell killing; tumor microenvironment; single-chain variable fragment (scFv); bispecific antibody; quadroma technology; knobs-into-holes; CrossMAb; bispecific T-cell engager (BiTE); antibody engineering; therapeutic biologics; immunoglobulin A; IgA; structure; FcαRI; CD89; immune evasion; therapeutic antibodies; IgM (immunoglobulin M); hexameric; pentameric; polymeric; polyvalency; joining chain (J-chain); avidity; complement dependent cytotoxicity (CDC); poly Ig receptor (pIgR)