Reprint

Drug Delivery of siRNA Therapeutics

Edited by
June 2020
286 pages
  • ISBN978-3-03936-200-4 (Hardback)
  • ISBN978-3-03936-201-1 (PDF)

This is a Reprint of the Special Issue Drug Delivery of siRNA Therapeutics that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary

The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs.

Format
  • Hardback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
Keywords
oligonucleotide delivery; light-activated release; intracellular release; liposome; indocyanine green; drug co-delivery; methotrexate; siRNA; antitumor effect; mixed micelles; targeted delivery system; cationic liposome; folate; folate receptor; cationic cholesterol derivative; siRNA delivery; gene knockdown; tumor-targeting; VEGFA; VEGFR1; endoglin; siRNA delivery; peptide; angiogenesis; gene silencing; migration; proliferation; endothelial cells; RNAi therapeutics; siRNA delivery; amphiphilic dendrons; PAMAM dendrimers; self-assembling; nanovectors; gene silencing; RNAi therapeutics; siRNA delivery; covalent dendrimers; PAMAM dendrimers; nanovectors; gene silencing; NABDs; siRNA; liposomes; clinical trials; siRNA; drug delivery; nanoparticle; carbonate apatite; ERBB2; AKT; breast cancer; ovarian cancer; siRNA; polymer; lipid; delivery; poly(ethylene) imine; PEI; RNA; siRNA delivery; tyrosine-modification; tumor xenograft; magnetic nanoparticle; iron oxide; siRNA delivery; BCL2; BIRC5/survivin; oral cancer; siRNA; aptamers; cancer; nanoparticles; siRNA; STAT6; polyaspartamide; pegylation; polyamine; polyplexes; asthma; n/a

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