Reprint
Extracellular Matrix in Development and Disease
Edited by
February 2019
356 pages
- ISBN978-3-03897-570-0 (Paperback)
- ISBN978-3-03897-571-7 (PDF)
This book is a reprint of the Special Issue Extracellular Matrix in Development and Disease that was published in
Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary
The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.
Format
- Paperback
License
© 2019 by the authors; CC BY-NC-ND license
Keywords
thrombospondins; cardiac remodeling; cardiac hypertrophy; heart failure; atherosclerosis; myocardial infarction; cardiac fibrosis; plasminogen activator inhibitor type 1; trophoblast invasion; recurrent pregnancy losses; preeclampsia; intrauterine growth restriction; gestational diabetes mellitus; endometriosis; polycystic ovary syndrome; fetal tenascin-C; pulmonary hypertension; vascular remodeling; right ventricular dysfunction; Duchenne muscular dystrophy; fibrosis; glucocorticoids; myogenesis; mdx mouse; versican; hyaluronan; kidney; interstitium; medulla; endothelin; vasopressin; angiotensin II; heart; protease; tryptase; chymase; TNF-α; collagen; extracellular matrix; histamine; extracellular matrix; hyaluronan; inter-alpha-trypsin inhibitor; tumor necrosis factor-alpha-induced protein 6; pentraxin 3; oocyte-cumulus complexes; integrin; extracellular matrix; counterreceptor; disintegrin; immune system; stem cell; pathogen; virus; bacteria; venom; growth factor; hormone; collagen II; chondrodysplasia; mutation; unfolded protein response; triple helix; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; liver fibrosis; secretome; metalloproteinase; extracellular matrix; ADAMTS; somite; muscle; zebrafish; microfabrication; extracellular matrix; cancer; metastasis; cancer metastasis; platelet; biomarker; cancer therapy; skeletal muscle; tissue engineering; angiogenesis; microenvironment; collagen; extracellular matrix; skin defects; bone fragility; muscle weakness; skeletal muscle engineering; tissue engineering; volumetric muscle loss; decellularized tissue; decellularized muscle; acellular tissue; acellular muscle; skeletal muscle regeneration; porcine; breast cancer; extracellular matrix; hydrogel; tissue matrix scaffold; scaffold; 3D culture; tumour microenvironment; cancer progression; extracellular matrix; matrix remodelling; fibrosis; extracellular matrix; hereditary diseases; reproduction; cancer; muscle; tissue engineering; integrins