Reprint

Calcium Signaling in Human Health and Diseases

Edited by
January 2019
462 pages
  • ISBN978-3-03897-537-3 (Paperback)
  • ISBN978-3-03897-538-0 (PDF)

This book is a reprint of the Special Issue Calcium Signaling in Human Health and Diseases that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary

Intracellular Ca2+ signaling is witnessing an amazing resurgence of interest. In addition to traditional Ca2+ aficionados, an astonishing (and growing) number of colleagues from all around the world have started to devote a large part of their research to gain insights into the role of Ca2+ signaling in health and disease. This is why calcium ions interact with virtually every signal transduction pathway not only in mammalian cells, but also across the phylogenetic tree, thereby, driving or modulating most, if not all, cellular functions, ranging from fertilization to apoptosis, passing through learning and memory, cardiac contractility, and immune response. This book gathers a collection of original research articles and reviews by a number of renowned experts who aim to present the state of the art of many pathophysiological aspects of intracellular Ca2+ signaling, such as embryonic development, immune response, extracellular Ca2+ signaling, neoplastic transformation, muscle hypertrophy, pulmonary inflammation, and P2X receptor gating.

Format
  • Paperback
License
© 2019 by the authors; CC BY-NC-ND license
Keywords
P2X4; ATP; calcium; monocyte; macrophage; purinergic receptor; Ca2+ signaling; tumor; endothelial cells; endothelial progenitor cells; endothelial colony forming cells; anticancer therapies; VEGF; resistance to apoptosis; SERCA2; acetylation; HDAC inhibition; ATPase activity; calcium transients; cardiomyocyte mechanics; ataxia; cerebellum; congenital disorders of glycosylation; magentic resonance Imaging (MRI); stroke-like; CaV2.1 voltage-gated calcium channel; cardiac hypertrophy; transcription factors; calmodulin; GRK; neurovascular coupling; neuronal activity; brain endothelial cells; Ca2+ signaling; glutamate; acetylcholine; ATP; nitric oxide; endothelial-dependent hyperpolarization; TRP channels; Ca2+-signalling; microelectrode; fluorophore; exocytosis; cAMP signalling; parathyroid extracellular-Ca2+-sensing receptor (CaR); cancer; apoptosis; ischemia/reperfusion; hypertrophy; heart; cardiomyocytes; calcium handling; SERCA2a; chronic heart failure; clinical trial; adeno-associated virus (AAV); gene delivery; Ca2+ signaling; Ca2+ influx; plasma membrane; endoplasmic reticulum; phospholipase C; Fura-2; Ca2+ fluorescent sensors; herbal extract; bioactive compounds; purinergic receptor channels; desensitization; ATP; calcium; allosteric; covalent; metastasis; nuclear import; myosin IC; calcium; prostate cancer; calcium signaling; T cell receptor (TCR); co-receptors; CD-5; PD-1; CTL-4; beta-estradiol; human uterine myometrium; telocytes; calcium signaling; voltage-gated calcium channels; estrogen receptors; Ca2+; STIM1; STIM2; SOCE; PDGF; PLCγ; melanoma; melanocyte; NMDAR; NLS; nuclear Ca2+-signalling; Ca2+-activated K+(BK) channel; calcium ions; cell cycle; AKT; cell volume; calcium ion channels; calcium channel blockade; sepsis; infection; immunosuppression; pulmonary surfactant; phosphatidylethanolamine; lung fibrosis; bleomycin model; lung fibroblasts; Ca2+ signaling; skeletal muscle; muscle hypertrophy; muscle atrophy; ATP; Ca2+; P2Y receptor; IP3 receptor; mammalian target of rapamycin (mTOR); mitogen-activated protein kinase (MAPK); KCa3.1 channels; glioblastoma; cell migration; calcium oscillations; mathematical model; astrocytes; calcineurin; neuronal activity; NMDA; mGluR5; store-operated calcium entry; calcium; development; embryo; human disease; animal model; Xenopus; zebrafish; mouse; intracellular calcium; endothelium; cell tracking; multi-target tracking; Kalman