Cyclic Nucleotide Signaling and the Cardiovascular System

© 2019 by the authors; CC BY license

sinoatrial node; HCN channel; funny current (I_f); cardiac pacemaking; cardiomyocyte; cell compartmentalization; phosphodiesterases; cyclic AMP (cAMP); ion channel; patch clamp; EPAC1; cyclic AMP; cyclic nucleotide binding domain; inflammation; endothelial cells; high-throughput screening; adenylyl cyclase; A-kinase anchoring proteins; cyclic AMP; cardiomyocytes; cAMP; cGMP; phosphodiesterase; FRET; imaging; cross-talk; cyclic nucleotide; G protein-coupled receptor; interleukin 6; myocardial infarction; inflammation; protease-activated receptor; protein kinase; Smad3; Stat3; vascular smooth muscle; A-kinase anchoring proteins; single nucleotide polymorphisms; genetic mutations; cardiovascular diseases; protein kinase A; phosphodiesterase 4; cardiac myocyte; vascular endothelium; cAMP; Epac; compartmentalization; A-kinase anchoring proteins; phosphodiesterases; cyclic nucleotides; cAMP; cGMP; phosphodiesterase; PDE3; intracellular signalling; heart; A-kinase anchoring protein (AKAP); protein kinase A; cyclic AMP; cardiomyocyte; cardiac protection; signal transduction; cAMP; compartmentalization; A-kinase anchoring proteins (AKAP); cyclic nucleotide phosphodiesterases (PDE); PDE inhibitors; 3′,5′-cyclic adenosine monophosphate; protein kinase A; fluorescence resonance energy transfer; real-time imaging; compartmentalisation; signalling; cardiac biology; phosphodiesterases; A kinase anchoring proteins; Popeye domain; cAMP binding; effector protein; cardiac arrhythmia; limb-girdle muscular dystrophy; atrioventricular block; cyclic guanosine 3′-5′ monophosphate; nitric oxide; vascular smooth muscle cells; cGMP-dependent protein kinase type I; atherosclerosis; cell plasticity; transdifferentiation; cell fate mapping; imaging; phosphodiesterases (PDEs); PDE1; cyclic nucleotide; cardiac hypertrophy; cardiac dysfunction; cAMP; phosphodiesterase; FRET; atrial; ventricle; iPSC-CMs; T-tubule; caveolae; development; adcy10; cAMP; phosphodiesterase; compartmentalization