Reprint

Cutting Edge Preclinical Models in Translational Medicine

Edited by
July 2020
262 pages
  • ISBN978-3-03936-138-0 (Hardback)
  • ISBN978-3-03936-139-7 (PDF)

This book is a reprint of the Special Issue Cutting Edge Preclinical Models in Translational Medicine that was published in

Medicine & Pharmacology
Public Health & Healthcare
Summary

In vitro, in vivo, and in silico preclinical models hold a widely acknowledged potential, yet complex limitations. For this reason, which has been known for a long time by experimenters and modelers, the translation of “science products” to the clinic is still far. Therefore, there is a raising awareness of the need to bridge this gap by developing integrated and innovative models. Organ and tissue bioengineering is an ideal approach to foster innovative strategies in significant research and clinical areas. Similarly, in translational neuroscience research, this challenge has been taken up by intriguing fish models. However, much research based on novel methodologies has still to be performed to get the bench closer to the bedside.

Format
  • Hardback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
chondrosarcoma; primary cell lines; cancer stem cells; whole exome sequencing; genomic drift; animal model; cancer preclinical model; neurotrophin-6; phylogeny; LNA probe; riboprobe; neuroanatomy; fish; aging; 3D bioprinting; biofabrication; 3D cultures; iPSCs; cortical neurons; calcium imaging; patch clamp; induced pluripotent stem cells; tissue engineering; angiogenesis; tissue regeneration; from bench to bedside; additive manufacturing; bioprinting; drug delivery; microparticles; scaffold; soft lithography; vascularization; translational medicine; preclinical imaging; rodent models; oncology; magnetic resonance imaging; normothermic machine perfusion; rat; human red blood cells; oxygen consumption; oxygen delivery; skin substitutes; tissue engineering; wound healing; extracellular matrix; bottom-up tissue engineering; vascularization; bioreactors; dermal substitutes; scar tissue; reelin; LIS2; ADLTE; autism; schizophrenia; translational models; GABAergic interneurons; dendritic spines; forebrain; cerebellum; multimodal imaging; hybrid imaging; positron emission tomography/magnetic resonance imaging (PET/MRI), nanotechnology; nanoparticles; in vivo imaging; 3D reconstruction; Nesf-1; vertebrate; Nothobranchius furzeri; aging; brain-gut axis; n/a