Heterocycles in Medicinal Chemistry

doi:10.3390/books978-3-7258-8316-5

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Keywords

reversine; microwave-assisted synthesis; molecular docking; cell cycle arrest; endoreduplication; p53; phenanthridines; benzo[c]phenanthridines; radical cyclization; antiproliferative; antibacterial activity; dibasic phenylcarbamates; surface tension; electronic properties; lipophilicity; Mycobacterium spp.; Imidazoles; phenolic compounds; antifungal activity; MIC; antioxidant capacity; structure-activity relationship; visnagenone; khellinone; quinazolinone; pyrimidine; thiazole; pyrazole; furane; antimicrobial activity; hyperthyroidism; thiouracil; pyrimidine; antithyroid; PTU; LPO; quorum sensing; biofilm; quinolones; molecular docking; molecular dynamics; piperazine-2,5-diones; theophylline; permeation; skin; Franz diffusion cell; HPLC determination; cytotoxicity; Luotonin A; quinazoline; quinoline; cycloaddition; catalytic transfer hydrogenation; Topoisomerase I; cytotoxic activity; thiazolyl-coumarin; HDACs inhibitor; cardiac fibroblasts; antifibrotic; ursolic acid analogues; synthesis; nitrogen heterocycles; apoptosis; antitumor activity; mesoporous silica; 5-fluorouracil; desorption; RP-UHPLC; L1210 cells; P-glycoprotein; multidrug resistance; phenanthroquinolizidine alkaloids; apoptosis; cinnoline; biological activity; heterocyclic compounds; oligonucleotides; bridged nucleic acids; locked nucleic acids; antisense; antibiotic resistance; hypercholesterolemia; myotonic dystrophy; CRISPR; Cas9; hematologic malignancies; thiazolylhydrazone; acetylcholinesterase; butyrylcholinesterase; enzyme inhibition; docking; nicergoline; aminoborane; CSD; single crystal; X-ray structure; dihydrogen bond; 3-aminoflavone; X-ray crystallography; fluorescence; LOD (limit of detection); LOQ (limit of quantification); concentration quenching; acute myeloid leukemia (AML); naphthoquinone; reactive oxygen species (ROS); apoptosis; mechanism of action; n/a

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Heterocycles in Medicinal Chemistry

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August 2026

356 pages

ISBN 978-3-7258-8315-8 (Hardback)
ISBN 978-3-7258-8316-5 (PDF)

https://doi.org/10.3390/books978-3-7258-8316-5

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This is a Reprint of the Special Issue Heterocycles in Medicinal Chemistry that was published in

Chemistry & Materials Science

Summary

Heteroatoms are increasingly appearing in drug structures, which is related to the progress being made in synthetic methodologies and the advantages of using heterocycles, as they can easily modify the pharmacokinetics and pharmacodynamics of bioactive agents. Thus, heterocycles have gained fundamental importance in drug design, and it is not surprising that a wide range of contributions based on heterocycles are published in this Reprint. Specifically, it includes 2 review articles and 17 original scientific articles.