66,032 Results Found

Protecting-group-free glycosylation reduces the steps needed to convert native sugars into glycosides, but selectivity and product isolation remain major limits. This review examines methods published mainly from 2024 to August 2026. It compares dono...

Aronia melanocarpa (black chokeberry) is a polyphenol-rich berry recognized as a functional food because of its potent antioxidant properties. This study investigated the phenolic composition, antioxidant capacity, and nephroprotective effects of A. ...

Indolo[1,2-a]quinoline derivatives represent an attractive heterocyclic scaffold in anticancer drug discovery. Herein, fifty-four novel indolo[1,2-a]quinoline-7-carbonitrile analogs were synthesized via a transition-metal-free cascade reaction involv...

To address the persistent challenges of low yield and significant batch-to-batch variability inherent in the traditional plant-based extraction of horseradish peroxidase (HRP), this study aimed to develop an efficient production strategy for HRP-C th...

Coumarin-based molecular hybrids provide a framework for examining how structural changes influence cellular responses. This study compared four hybrids and three reference compounds across ten human cancer cell lines, with the lead hybrid also teste...

Anthropogenic underground systems are challenging to monitor because restricted ventilation, particle retention, resuspension and spatial heterogeneity generate complex elemental patterns. We tested whether controlled active moss-bag biomonitoring su...

The microbiota–gut–brain axis (MGBA) is a complex signaling network linking the gut microbiota with central nervous system function. Growing evidence suggests that gut microbial dysbiosis contributes to neurodegenerative diseases (NDs) th...

Extracellular vesicles (EVs) have emerged as promising therapeutic carriers owing to their biocompatibility, low immunogenicity, and ability to transport diverse biological cargo. However, successful EV-based therapy depends not only on carrier engin...

The widespread use of pesticides in modern agriculture contributes to a range of environmental and food-safety concerns, including the persistence of chemical residues in food products, contamination of soil and water, and potential risks to human an...

Automated bonded-force-field generation for metal-containing molecular systems remains a practical bottleneck because it is expertise-intensive and computationally demanding. RapidMetalFF-AI converts this fragmented process into a minute-scale automa...

Background: Wild-growing Cannabis sativa L. represents an underexplored source of hemp-type plant material, but its value for future selection depends on standardized morphological and phytochemical characterization. This study evaluated cultivated M...

A series of 11 compounds of phenyl–imidazole–pyrrole and 9 compounds of phenanthryl–imidazole–pyrrole were synthesized and evaluated against breast cancer cell lines differing in the expression of estrogen receptor (ER), proge...

Zeolite-P is a synthetic member of the gismondine (GIS) framework family and is intrinsically microporous, with intersecting eight-membered-ring channels. Mesoporosity reported for some Zeolite-P samples is therefore a secondary textural feature aris...

Aqueous rechargeable batteries are promising candidates for large-scale energy storage owing to their inherent safety, low cost, and environmental compatibility, yet the narrow 1.23 V electrochemical stability window (ESW) of water limits their energ...

Electrochemical CO₂ reduction to formic acid is a promising approach for carbon valorization, but achieving both high productivity and Faradaic efficiency remains a major challenge. In this study, a Bi–O–S electrocatalyst was synthesized...

The genus Stachys L. genus is in the Lamiaceae family; comprises many numerous medicinally important taxa traditionally used in Anatolia for nutritional and therapeutic purposes. Many Stachys taxa Stachys species have been employed in folk medicine f...

Contamination of feed with zearalenone (ZEN) poses a threat to animal and human health, which drives interest in low-cost sorbents derived from plant waste. For non-activated biochars, the properties that govern ZEN binding remain not fully studied....

In Figure 1a of the original publication [...]

Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota and intestinal health, yet their analysis is challenging due to high volatility, hydrophilicity, and the complexity of the faecal matrix. This study introduces a novel, green, and f...

Transition metal sulfides and oxides are attractive for supercapacitor electrodes due to rich redox sites and high theoretical capacitances. Yet single-phase materials suffer from poor structural stability and slow charge transfer, restricting practi...

Epidermal barrier damage triggers sensitive skin disorders. Synthetic skin repair agents frequently incur irritation, whereas medicinal and edible herbal ingredients offer milder alternatives. As a traditional Chinese medicinal herb, Atractylodes mac...

Glioblastoma (GBM) is a highly aggressive type of brain cancer for which only a limited number of therapeutic options are available, highlighting the need to use multi-target strategies that interfere with the mechanisms by which the tumor survives a...

Transparent cellulose papers used as substrates have gained increasing attention in the flexible optoelectronics field. However, significant challenges remain in overcoming the hydrophilicity of transparent cellulose papers and endowing them with con...

Electrochemical water splitting is a core component of clean and renewable energy technologies. Developing low-cost, highly active electrocatalysts is critical to enabling its large-scale deployment. Interfacial effects, which govern charge-transfer...

Nonsense mutations introduce premature termination codons (PTCs) into mRNA transcripts, leading to truncated and non-functional proteins, and accounting for approximately 10–15% of genetic disorders. In this context, the induction of translatio...

Aluminum oxide nanoparticles (Al₂O₃ NPs) are frequently incorporated into fertilizers and pesticides. Nevertheless, the effects of Al₂O₃ NPs on plants growing in acidic soils with elevated aluminum toxicity remain poorly understood. In this context,...

Hepatic steatosis is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease worldwide. Lipotoxicity, resulting from excessive accumulation of fatty acids and bioactive lipid intermed...

Thermal processing facilitates the transformation of major ginsenosides into rare ginsenosides, thereby enhancing the bioactive molecular profile of American ginseng. This study examined the impact of 1–4 cycles of high-temperature and high-pre...

This study aimed to evaluate the impact of ultrasound-assisted extraction (UAE) on the chemical composition and biological activities of gabiroba waste oil (GWO), compared to conventional Soxhlet extraction (SE). GWO was characterized for carotenoid...

Professor Tang Youqi was a distinguished Chinese physical chemist and educator and one of the pioneers of structural chemistry and crystal chemistry in China [...]

Limoniastrum guyonianum Durieu ex Boiss. is an endemic halophyte native to the semi-arid regions of North Africa and represents an under-explored source of bioactive phytochemicals. This study investigated the phytochemical composition and anti-ureas...

The rapid emergence of antimicrobial resistance necessitates the development of novel antimicrobial agents with improved efficacy and favorable safety profiles. In this study, a new series of pyridine-3-carboxamide–1,3,4-thiadiazole hybrids and...

Although raspberries are widely valued for their health-promoting properties, comprehensive comparative studies integrating pomological quality traits, phenolic compounds, and antioxidant capacities across cultivars with distinct fruit colors remain...

Background/Objectives: In the production of functional foods, bioactive compounds are commonly incorporated into the product, including dietary fibre, polyols, probiotics and prebiotics, unsaturated fatty acids, vitamins, minerals, and other health-p...

The massive accumulation of poly(ethylene terephthalate) (PET) plastic waste poses a significant global environmental challenge, requiring the development of more sustainable upcycling strategies. This study investigated the alkaline hydrolysis of PE...

Diphenylpyraline analogs JKH1 and JKH10 are monoamine transporter inhibitors and promote relaxation in mouse mesenteric arteries. Here, we evaluated JKH1 and JKH for their interaction with CB₁ cannabinoid receptor signaling. In N18TG2 mouse neuroblas...

This review describes the principles of cold plasma generation and critically evaluates the effects of cold atmospheric plasma (ACP) and plasma-activated water (PAW) on the microbial safety, physicochemical quality, and preservation of meat products,...

Overpotential at 10 mA cm⁻² (η₁₀) is the default benchmark for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) electrocatalysts, but the number is rarely comparable across studies. This Perspective identifies six measu...

The contamination of water resources by heavy metals, radionuclides, and organic pollutants demands efficient materials for water treatment. Covalent organic frameworks (COFs) are promising candidates owing to their tunable porosity and functionaliza...

The increasing concentration of atmospheric carbon dioxide (CO₂) and the urgent need to mitigate anthropogenic greenhouse gas emissions have intensified scientific interest in developing sustainable carbon capture and utilization technologies [...]

CO₂ flooding is essential for enhancing oil recovery in low-permeability reservoirs; however, the large viscosity contrast between CO₂ and crude oil leads to severe gas channeling and low sweep efficiency. In this study, a binary composite system was...

Recently, photodeformable liquid crystalline polymer materials (LCPMs) have attracted tremendous attention owing to their fascinating photoresponsive properties and promising applications. However, conventional photodeformable LCPMs invariably depend...

The emergence of infections caused by Scedosporium/Lomentospora and Mucorales species poses a major clinical challenge due to their intrinsic resistance to multiple antifungal drugs and the limited number of therapeutic options available. In this stu...

Gross extraction yield alone cannot establish product conformity or broader economic and environmental performance. This critical integrative review examines evidence linking laboratory findings to industrially relevant claims for plant-derived biopr...

Larix sibirica is a conifer and a renewable source of chemically diverse constituents with pharmacological uses. This review examines its phytochemical composition, extraction strategies, and reported pharmacological activities, including preliminary...

Many studies confirm that natural substances derived from plant materials, at appropriate concentrations, can exhibit anticancer effects against various types of cancer cells. One such substance is hinokitiol, which has been proven to have anticancer...

Melanins were synthesized using a variety of precursors, some of which are precursors of naturally occurring eumelanin or allomelanin. Purified materials were evaluated using absorbance or FT-IR spectroscopy and compared for their common physical and...

Conformational sampling remains a major challenge in molecular dynamics (MD) simulations of proteins with large-scale functional motions. Here, we use apo Escherichia coli adenylate kinase (AdK) as a benchmark for the open–closed transition and...

This study investigated ethanol-based extraction of total flavonoids from vine tea (Ampelopsis grossedentata) leaves and characterized their chemical composition and in vitro biological activities. Ultrasound-assisted and heat-reflux extraction condi...

The escalating threat of antimicrobial resistance demands the discovery of antibacterial agents with unprecedented chemical scaffolds. Natural products have historically been the most prolific source of antibiotics, yet the vast majority of catalogue...