Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV and HTLV Infections and Coinfections submission deadline 30 Sep 2025 | 11 articles | Viewed by 20967 | Submission Open
Keywords: human T-cell leukemia virus; HIV; HTLV-associated diseases; HIV co-infections
(This special issue belongs to the Section Human Virology and Viral Diseases)
Recent Advances in Antiviral Natural Products 2025 submission deadline 30 Sep 2025 | 6 articles | Viewed by 18634 | Submission Open
Keywords: virus; antiviral; host-defense; natural product; drug delivery; infectious disease
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Host Cell-Virus Interaction, 4th Edition submission deadline 30 Sep 2025 | 6 articles | Viewed by 11829 | Submission Open
Keywords: virus; viral proteins; virus entry; viral replication and pathogenesis; virus assembly and egress; intracellular trafficking of virus; host cell; cellular signaling; interferon pathway; inflammasome; viral immune evasion; immune response; cell death; apoptosis; autophagy; host-virus interaction; anti-viral strategies; direct acting antivirals; broad-spectrum antiviral agents; RNAi; microRNAs; neutralizing antibodies; molecular mechanisms of antivirals; molecular mechanisms of drug-resistance
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Insect Viruses and Pest Management, the Third Edition submission deadline 30 Sep 2025 | 8 articles | Viewed by 11123 | Submission Open
Keywords: insect-specific viruses; pest control; virus-based biocontrol agents; quality control; industrial production; resistance development to virus-based biocontrol agents
(This special issue belongs to the Section Invertebrate Viruses)
Viruses and Eye Diseases
edited by Homayon Ghiasi and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 6282 | Submission Open
Keywords: ocular health; herpesviruses; herpes simplex virus (HSV); varicella zoster virus (VZV); adenovirus; respiratory viruses; Zika virus; cytomegalovirus (CMV); virus– ocular tissue interactions
(This special issue belongs to the Section Human Virology and Viral Diseases)
JC Polyomavirus
edited by and Anne-Sophie L'Honneur
submission deadline 30 Sep 2025 | 3 articles | Viewed by 6096 | Submission Open
Keywords: JC polyomavirus; progressive multifocal leukoencephalopathy (PML); neurotropic variants; viral genomic rearrangements
(This special issue belongs to the Section Human Virology and Viral Diseases)
Computational Biology of Viruses: From Molecules to Epidemics, Volume 2
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 5875 | Submission Open
Keywords: mathematical modeling; simulation modeling; molecular processes; within-host dynamics; epidemiological models; multiscale models
(This special issue belongs to the Section General Virology)
Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)
edited by and Fei Yu
submission deadline 30 Sep 2025 | 6 articles | Viewed by 5595 | Submission Open
Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals
(This special issue belongs to the Section Coronaviruses)
Mechanism of Receptor Recognition in Coronavirus, 2nd Edition
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4042 | Submission Open
Keywords: receptor recognition; spike protein adaptations; receptor-binding domain (RBD); host range and zoonotic transmission; viral evolution and immune evasion; glycosylation and co-receptors; proteolytic activation; therapeutic and vaccine strategies; cross-species viral transmission; pandemic preparedness and surveillance
(This special issue belongs to the Section Animal Viruses)
Mechanisms of Herpesvirus Resistance
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4008 | Submission Open
Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral Diseases of Livestock and Diagnostics, 2nd Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3338 | Submission Open
Keywords: viral disease; zoonosis; zooanthroponosis; production animal
(This special issue belongs to the Section Animal Viruses)
Diversity and Evolution of Viruses in Ecosystem 2025
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3334 | Submission Open
Keywords: environmental virology; viral metagenomics; viral metatranscriptomics; phage genomics; virus evolution and phylogeny
(This special issue belongs to the Section General Virology)
Dual Nature of Bacteriophages: Friends or Enemies in Food Industry? submission deadline 30 Sep 2025 | 3 articles | Viewed by 3308 | Submission Open
Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne sapro-phytic bacteria
(This special issue belongs to the Section Bacterial Viruses)
Animal Herpesvirus 2025
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3057 | Submission Open
Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility
(This special issue belongs to the Section Animal Viruses)
Viral Diseases of Sheep and Goats
edited by Ramsés Reina and Álex Gómez
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2759 | Submission Open
Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines
(This special issue belongs to the Section Animal Viruses)
Application of Plant Viruses in Biotechnology submission deadline 30 Sep 2025 | 1 articles | Viewed by 2118 | Submission Open
Keywords: plant viruses; viral nanoparticles; plant viral vectors; biotechnological applications
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Broadly Protective Anti-Viral Vaccines 2025
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1887 | Submission Open
Keywords: universal vaccines; structure-based rational design; cross-protection; broadly neutralizing antibody; T-cell epitopes; preventative and therapeutic vaccines; adaptive immunology; highly variable virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses submission deadline 30 Sep 2025 | 1 articles | Viewed by 1403 | Submission Open
Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions
(This special issue belongs to the Section Animal Viruses)
Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System
edited by Karin E. Peterson and Amanda E. Calvert
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1402 | Submission Open
Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Molecular Epidemiology of SARS-CoV-2, 4th Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1338 | Submission Open
Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology
(This special issue belongs to the Section Coronaviruses)
Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 855 | Submission Open
Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Pathogenesis of Viral Infections
edited by
submission deadline 30 Sep 2025 | Viewed by 393 | Submission Open
Keywords: human and zoonotic viral diseases; viral pathogenesis; systems-level analyses; immune response; protein– protein interactions
(This special issue belongs to the Section General Virology)
Giant, Jumbo and Mega Phages
edited by
submission deadline 30 Sep 2025 | Viewed by 345 | Submission Open
Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications
(This special issue belongs to the Section Bacterial Viruses)
Viral Strategies to Regulate Host Immunity or Signal Pathways 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 344 | Submission Open
Keywords: virus– host interaction; viral immunity; viral pathogenesis; immune evasion; innate immunity; adaptive immunity; signal pathway
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Therapeutic Interfering Particles (TIPs): A Promising Treatment for Viral Infections
edited by and Rebekah Honce
submission deadline 30 Sep 2025 | Viewed by 337 | Submission Open
Keywords: defective interfering particles; defective viral genomes; therapeutic interfering particles; DIPs; DVGs; TIPs
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral Pathogenesis and Novel Vaccines for Fish Viruses
edited by Vikram Vakharia
submission deadline 30 Sep 2025 | Viewed by 251 | Submission Open
Keywords: fish; RNA viruses; viral pathogenesis; virulence; reverse genetics; recombinant vaccines; oral vaccines
(This special issue belongs to the Section Animal Viruses)
15-Year Anniversary of Viruses submission deadline 1 Oct 2025 | 11 articles | Viewed by 16571 | Submission Open
Keywords: diversity; innovation; and impact of modern virology research; virology across all domains; Viruses  fifteenth year anniversary  
(This special issue belongs to the Section General Virology)
Women in Virology 2025
edited by , , Priti Kumar and Ulrike Lange
submission deadline 1 Oct 2025 | 6 articles | Viewed by 14016 | Submission Open
Keywords: human; animal; and plant viruses; virus replication; pathogenesis; transmission; antivirals; antiviral resistance; drug discovery; vaccine development and evaluation; animal models; high-risk populations
(This special issue belongs to the Section General Virology)
Viral Infection in Airway Epithelial Cells
edited by Camille Ehré and Raymond J. Pickles
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1851 | Submission Open
Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract
(This special issue belongs to the Section Animal Viruses)
Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside
edited by , and David Hillyard
submission deadline 15 Oct 2025 | Viewed by 427 | Submission Open
Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral RNA and Its Interaction with the Host
edited by and Neva Caliskan
submission deadline 24 Oct 2025 | 2 articles | Viewed by 5742 | Submission Open
Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization
(This special issue belongs to the Section General Virology)
Pestivirus 2025
edited by and Christiane M. Riedel
submission deadline 30 Oct 2025 | 3 articles | Viewed by 2214 | Submission Open
Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF
(This special issue belongs to the Section Animal Viruses)
Mosquito-Borne Encephalitis Viruses submission deadline 31 Oct 2025 | 13 articles | Viewed by 22687 | Submission Open
Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses
(This special issue belongs to the Section Human Virology and Viral Diseases)
Innate and Adaptive Immune Responses to Arbovirus Infections
edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and
submission deadline 31 Oct 2025 | 3 articles | Viewed by 10696 | Submission Open
Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viruses Associated with Gastroenteritis submission deadline 31 Oct 2025 | 6 articles | Viewed by 6359 | Submission Open
Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 5632 | Submission Open
Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV Neurological Disorders: 2nd Edition
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 5480 | Submission Open
Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology
(This special issue belongs to the Section Human Virology and Viral Diseases)
Biotechnological Applications of Phage and Phage-Derived Proteins 2025
edited by
submission deadline 31 Oct 2025 | 2 articles | Viewed by 5060 | Submission Open
Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic
(This special issue belongs to the Section Bacterial Viruses)
Viral Hemorrhagic Disease
edited by Joseph W. Golden and Aura R. Garrison
submission deadline 31 Oct 2025 | 3 articles | Viewed by 4031 | Submission Open
Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses
(This special issue belongs to the Section Animal Viruses)
Bunyaviruses 2025
edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich
submission deadline 31 Oct 2025 | 3 articles | Viewed by 3318 | Submission Open
Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics
(This special issue belongs to the Section General Virology)
Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 2233 | Submission Open
Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure
(This special issue belongs to the Section Human Virology and Viral Diseases)
Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1632 | Submission Open
Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance
(This special issue belongs to the Section Animal Viruses)
Economically Important Viruses in African Crops
edited by James Peter Legg, Stephen Winter, and
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1609 | Submission Open
Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Current ART, Virologic Failure and Implications for HIV Drug Resistance, 2nd Edition
edited by Susan M. Schader
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1394 | Submission Open
Keywords: antiretroviral therapy (ART); HIV; AIDS; drug resistance; low level viremia (LLV); very low level viremia (VLLV); virologic failure (VF); clinical failure; viral load (VL); viral suppression; long-acting injectables (LAI); pre-exposure prophylaxis (PrEP); first-line ART; second-line ART; target detected; target not detected (TND); viral blips; novel mechanisms of HIV drug resistance; acquired genotypic drug resistance; adherence; people living with HIV (PLWH); management of people living with HIV (PLWH); risk factors; genotype; phenotype; treatment efficacy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics
edited by and Sunmi Lee
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1294 | Submission Open
Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics
(This special issue belongs to the Section General Virology)
Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1041 | Submission Open
Keywords: vaccines; antiviral drugs; domestic animals; virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Regulation of HIV-1 Transcription and Latency, 2nd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 983 | Submission Open
Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir
(This special issue belongs to the Section Human Virology and Viral Diseases)
Enteric Viruses in Environment and Humans: Identification, Surveillance and Control
edited by and Maria Inês Zanoli Sato
submission deadline 31 Oct 2025 | 1 articles | Viewed by 933 | Submission Open
Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health
(This special issue belongs to the Section Human Virology and Viral Diseases)
One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans submission deadline 31 Oct 2025 | Viewed by 619 | Submission Open
Keywords: One Health; spillover; viruses; emerging viruses
(This special issue belongs to the Section Animal Viruses)
Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO) submission deadline 31 Oct 2025 | Viewed by 541 | Submission Open
Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk
(This special issue belongs to the Section Human Virology and Viral Diseases)
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