Special Issue "Marine Biotoxins: Novel Issues about Old Compounds"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 December 2009)
Prof. Dr. Gian Paolo Rossini
Università di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Via Campi 287, 41100 Modena, Italy
Phone: +39 059 205 5388
Fax: +39 059 205 5410
Interests: signal transduction; receptors; marine biotoxins; molecular mechanisms of toxicity; toxicity pathways; proteomics; biomarkers; functional methods of toxin detection; cell adhesion; cell proliferation; cell death; cell cultures
Human poisonings due to exposures to marine biotoxins have occurred in the past and represent naturally occurring events, that have been attracting an increasing interest from the scientific community.
The last ten years, in particular, have witnessed a growing body of knowledge on the chemistry, mechanisms of action, toxicity, ecology and distribution, as well as the health impact of marine biotoxins. Research efforts have led to a deeper understanding of many aspects of marine biotoxins and their impact on living organisms, while novel issues have been recognized. For instance, “new” toxin producers have been identified, and “old” ones are being characterized using molecular probes. The number of toxins isolated, chemically characterized and/or synthesized has increased, and new groups of biotoxins have been discovered. Likewise, the methodology for toxin detection has been continuously developed, providing both instrumental and bio-molecular options. Biochemical tools have been increasingly used to clarify the mechanisms of action of toxins, and the “omic” approaches have entered the biotoxin field. The toxicology of biotoxins has been advancing, taking into consideration the real conditions of human and animal exposure to these compounds.
It’s time to gather the information available on novel issues in marine biotoxins, to critically evaluate what we know and pinpoint the many unknowns, thereby providing a broad perspective to support the scientific community in its next efforts to understand and exploit the complexity of the chemistry and biology of marine biotoxins.
Prof. Dr. Gian Paolo Rossini
- toxin producers
- toxin synthesis
- instrumental analysis
- functional assays
- mechanisms of action
- transcription profiles
- combined toxicity
- Marine Biotoxins: Novel Issues about Old Compounds in Marine Drugs (4 articles)
Toxins 2010, 2(7), 1646-1675; doi:10.3390/toxins2071646
Received: 29 April 2010; in revised form: 28 May 2010 / Accepted: 11 June 2010 / Published: 28 June 2010| Cited by 4 | PDF Full-text (1071 KB) | HTML Full-text | XML Full-text
Article: PP2A Inhibition Assay Using Recombinant Enzyme for Rapid Detection of Okadaic Acid and Its Analogs in Shellfish
Toxins 2010, 2(1), 195-204; doi:10.3390/toxins2010195
Received: 27 November 2009; in revised form: 18 January 2010 / Accepted: 19 January 2010 / Published: 25 January 2010| Cited by 10 | PDF Full-text (325 KB) | HTML Full-text | XML Full-text
Last update: 7 August 2014