New Developments in Statistical Design and Analysis of Clinical Trials

Dear Colleagues,

We cordially invite you to contribute to a Special Issue on "New Developments in Statistical Design and Analysis of Clinical Trials" with an original research article or comprehensive review. The submissions will be evaluated through the peer-review system of Mathematics.

Clinical trials play a pivotal role in advancing medical knowledge and patient care. As the complexity of clinical research grows, so does the need for innovative statistical designs and analytical methods to ensure the validity and efficiency of trial results. Such developments can help researchers to make better decisions during the trial process, reduce the required sample sizes, and improve the overall quality of evidence generated from clinical trials.

The focus of this Special Issue is on new and innovative statistical methodologies for the design and analysis of clinical trials. Topics of interest include but are not limited to:

• Novel trial designs, such as adaptive and Bayesian designs;
• Methods for handling missing data and informative censoring;
• Techniques for analyzing high-dimensional and complex data structures;
• Innovations in the evaluation of treatment effects, including causal inference and subgroup analysis;
• Approaches for addressing multiplicity and interim analyses;
• Statistical methods for monitoring safety and efficacy during the trial.

By showcasing the latest advancements in statistical design and analysis of clinical trials, this Special Issue aims to promote the development and application of cutting-edge methodologies in clinical research, ultimately benefiting patients and the broader medical community.

We look forward to receiving your valuable contributions and fostering insightful discussions on this important topic.

Dr. Xianming Tan
Dr. Jianping Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Mathematics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.