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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing Personalized Spine Surgery Through Minimally Invasive Techniques—Perspectives from Inter-American Society for Minimally Invasive Spine Surgery (SICCMI)

edited by

Kai-Uwe Lewandrowski

submission deadline 10 Dec 2025 | 2 articles | Viewed by 9662 | Submission Open

Keywords: spine surgery; minimally invasive techniques; personalized care; personalized medicine; precision imaging; 3D printing in orthopedics; biomarkers in spinal health; artificial intelligence in surgery; robotics in spine surgery; genomics and spinal disorders; pain management and rehabilitation; surgical navigation systems; biocompatible materials for implants; patient-specific surgical planning; regenerative medicine in spine health; future trends in spinal surgery

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Complications in Vascular Surgery: Current Updates and Perspectives

edited by

Yamume Tshomba

submission deadline 10 Dec 2025 | 1 articles | Viewed by 566 | Submission Open

Keywords: endoleak; visceral ischaemia; lower limb ischaemia; graft infection; aneurysm shrinkage; sac growing; transient ischemic attack; stroke; deep vein thrombosis; vascular injuries; embolization

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Psychiatry: Challenges and Opportunities

edited by

Gniewko Więckiewicz

submission deadline 20 Dec 2025 | 10 articles | Viewed by 36586 | Submission Open

Keywords: psychiatry; personalized medicine; epidemiology; public health; addictions; schizophrenia; depression; mental health; precision psychiatry; treatment response; genetic factors; biomarkers; pharmacogenomics; behavioral interventions; comorbidity; substance abuse; neurobiology; psychiatric disorders; psychosocial factors; population health

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advancements in Neurosurgical Oncology: Bridging Neurosurgery and Cancer Neuroscience

edited by

Andres M. Alvarez-Pinzon

submission deadline 20 Dec 2025 | 1 articles | Viewed by 13610 | Submission Open

Keywords: neuro-oncology; cancer progression; neural mechanisms in cancer; brain tumors; neurological implications of cancer; cancer-induced neuropathy; neural stem cells and cancer; neuroinflammation in cancer; neuroimaging in oncology; cancer therapeutics and neurological safety

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Integrating Mathematical Modeling and Data Analysis in Personalized Medical Research

edited by

Dorota Bielińska-Wąż

and

Piotr Wąż

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2294 | Submission Open

Keywords: personalized medicine; health informatics; mathematical modeling; data analysis; bioinformatics; artificial intelligence; machine learning

(This special issue belongs to the Section Omics/Informatics)

Personalized Medicine in Dental and Oral Health

edited by

Liliana Georgeta Foia

and

Magda Ecaterina Antohe

submission deadline 25 Dec 2025 | 4 articles | Viewed by 20207 | Submission Open

Keywords: oral health; systemic context; personalized medicine; pharmacogenomics; caries pathology; diagnostics; clinical evaluation; paraclinical evaluation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Laparoscopy, Perioperative Care and Complications in Surgery for Gastrointestinal Diseases

edited by Michał Kisielewski

submission deadline 25 Dec 2025 | 2 articles | Viewed by 4359 | Submission Open

Keywords: laparoscopy; perioperative care; colorectal surgery; minimally invasive surgery; upper digestive surgery; hepatobiliary surgery; postoperative complications

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Artificial Intelligence and Computational Approaches for Clinical Pharmacology and Drug Development

edited by Paraskevi F. Katsakiori and

Panagiotis Papadimitroulas

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2413 | Submission Open

Keywords: personalized medicine; artificial intelligence; optimized therapies; computational models; drug development; clinical pharmacology; machine learning; radiopharmaceuticals; prediction models; digital healthcare

(This special issue belongs to the Section Pharmacogenetics)

Advancing Personalized Medicine: Targeting Oxidative Stress in Neurodegenerative Diseases

edited by Lucia Buccarello

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1897 | Submission Open

Keywords: oxidative stress; neurodegeneration; biomarkers; neuroprotection; protein oxidation; neuroinflammation; protein degradation; personalized medicine; intracellular signaling; neuronal death

(This special issue belongs to the Section Mechanisms of Diseases)

Targeted Therapy and Biomarkers for Solid Tumors

edited by Anca Zgură and

Rodica Maricela Anghel

submission deadline 25 Dec 2025 | Viewed by 401 | Submission Open

Keywords: targeted therapy; biomarkers; solid tumors; oncology; cancer immunology; oncology radiotherapy; personalized medicine; molecular targets; drug resistance; translational research

(This special issue belongs to the Section Mechanisms of Diseases)

Inflammatory Bowel Disease (IBD): Diagnosis and Personalized Treatment

edited by Abigail Raffner (formerly Basson)

submission deadline 25 Dec 2025 | Viewed by 323 | Submission Open

Keywords: inflammatory bowel disease; diagnostic tools; biomarkers; therapeutic strategies; molecular mechanisms; microbiome; genetic predispositions; environmental factors; personalized treatment

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Diagnosis and Therapy in Renal Cell Carcinoma

edited by Antonio Nacchia

submission deadline 25 Dec 2025 | Viewed by 241 | Submission Open

Keywords: inflammation; kidney cancer; renal cell cancer; inflammatory markers

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Cancer Immunotherapy: Current Advancements and Future Perspectives

edited by

Stefano Forte

and

Gianluca Ferini

submission deadline 31 Dec 2025 | 8 articles | Viewed by 19482 | Submission Open

Keywords: personalized immunotherapy; molecular pathways in cancer immunotherapy; precision medicine; molecular markers; molecular bases of abscopal effect; sustained therapeutic response

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Obstetrics and Gynecology and Women's Health—2nd Edition

edited by

Panagiotis N. Tsikouras

submission deadline 31 Dec 2025 | 2 articles | Viewed by 18547 | Submission Open

Keywords: uterine fibroids; uterine myoma; leiomyoma; uterine artery embolization; endometriosis; gynecological surgery; infertility; endocrinology; hysteroscopy; hormonal therapies; personalized medicine

(This special issue belongs to the Section Sex, Gender and Hormone Based Medicine)

Clinical and Experimental Surgery in Personalized Molecular Medicine

edited by

Apostolos E. Papalois

and Manousos M. Konstadoulakis

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8086 | Submission Open

Keywords: personalized molecular medicine; clinical practice; surgical research; surgical oncology; multidisciplinary approaches

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Recent Research on Personalized Approaches to Clinical Therapeutics and Medication Safety

edited by

Sheraz Ali

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5564 | Submission Open

Keywords: clinical therapeutics; medication safety; pharmacotherapy; personalized medicine; treatment optimization; polypharmacy

(This special issue belongs to the Section Epidemiology)

Biomarkers and Pathogenesis of Infectious Diseases: From Research to Personalized Medicine

edited by

César Henríquez-Camacho

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3853 | Submission Open

Keywords: biomarkers; infectious diseases; pathogenesis; personalized medicine

(This special issue belongs to the Section Disease Biomarkers)

Digital Pathology in Translational Medicine and Clinical Practice

edited by

Alessandro Caputo

Vincenzo L'Imperio

and Filippo Fraggetta

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3401 | Submission Open

Keywords: digital pathology; computational pathology; integrative pathology; computer-aided diagnosis; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Mechanisms of Diseases)

Advances in Transfusion Medicine and Immunological Research

edited by Luca Mele

submission deadline 31 Dec 2025 | 1 articles | Viewed by 598 | Submission Open

Keywords: transfusion medicine; immunological responses; blood safety; cellular therapy; alloimmunity

(This special issue belongs to the Section Mechanisms of Diseases)

Innovative and Future Trends in Personalized Medicine for Retinal Diseases

edited by Joanna Dolar-Szczasny

submission deadline 31 Dec 2025 | 1 articles | Viewed by 304 | Submission Open

Keywords: retinal disease; age-related macular degeneration; diabetic retinopathy; gene therapy; retinal biomarker; personalized medicine; retinal imaging; molecular profile; artificial intelligence in ophthalmology; inherited retinal diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in Platelet Disease

edited by

Tomas Jose Gonzalez-Lopez

submission deadline 31 Dec 2025 | Viewed by 234 | Submission Open

Keywords: personalized medicine; platelet-related pathologies; molecular biology; platelet dysfunction; molecular mechanisms; platelets

Personalized Medicine and Surgery in Cardiovascular Disorders

edited by

Quynh Nguyen

and Edward D. Percy

submission deadline 31 Dec 2025 | Viewed by 218 | Submission Open

Keywords: precision medicine; cardiovascular disorders; cardiogenetics; translational medicine; genomic and multi-omics approaches to cardiovascular diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Treatments in Thoracic Oncology Surgery

edited by

Georg Schlachtenberger

and Alberto Lopez

submission deadline 10 Jan 2026 | 2 articles | Viewed by 2695 | Submission Open

Keywords: minimally invasive surgery; TNM classification; adjuvant treatment; long-term survival

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

From Acute Injury to Personalized Prevention—Developing Modern Strategies

edited by

Markus Gesslein

and

Eduard Kurz

submission deadline 10 Jan 2026 | Viewed by 213 | Submission Open

Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Oxidative Stress and Antioxidant Therapy in Diseases

edited by

Evgenia Lymperaki

and

Ioannis Tsamesidis

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2824 | Submission Open

Keywords: oxidative stress; antioxidants; ROS; diseases; antioxidants

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Cardiovascular and Metabolic Diseases

edited by

Gaetano Santulli

submission deadline 15 Jan 2026 | Viewed by 246 | Submission Open

Keywords: cardiovascular disease; metabolic syndrome; precision health; telemedicine; biomarkers; pharmacogenomics; artificial intelligence; machine learning; epigenetics; diabetes

(This special issue belongs to the Section Mechanisms of Diseases)

New Perspectives, Challenges and Innovations in Modern Personalized Gynaecologic Oncology

edited by

Stamatios N. Petousis

submission deadline 20 Jan 2026 | 2 articles | Viewed by 15491 | Submission Open

Keywords: gynecologic oncology; surgical oncology; medical oncology; radiation oncology; diagnosis; ethics; palliative treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Approaches in Pharmacogenomics

edited by

Su-Jun Lee

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7142 | Submission Open

Keywords: personalized medicine; supporting tools/software for personalized medicine; pharmacogenomic test; pharmacogenomic education; drug response; genomic biomarker; functional genomics; healthcare system

(This special issue belongs to the Section Pharmacogenetics)

Clinical Research of Precision Neuro-Oncology

edited by

Giuseppe La Rocca

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2224 | Submission Open

Keywords: neuro-oncology; precision surgery; tailored treatment; innovation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Diagnosis, Treatment, and Survivorship of Lymphoma in the Era of Personalized Medicine

edited by Andrew Ip

submission deadline 20 Jan 2026 | Viewed by 230 | Submission Open

Keywords: lymphoma; non-Hodgkin lymphoma; Hodgkin lymphoma; personalized medicine; next-generation sequencing; early detection; survivorship

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

New Insights into Cardiac Electrophysiology and Personalized Medicine

edited by Ioanna Koniari

submission deadline 20 Jan 2026 | Viewed by 170 | Submission Open

Keywords: ablation; AF; PVI; PFA; ventricular arrhythmias; supraventricular arrhythmias; pacemakers; ICDs; CRT; conduction system pacing

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Critical Care Medicine: Novel Challenges and Advances

edited by

Fernando Ramasco-Rueda

submission deadline 25 Jan 2026 | 2 articles | Viewed by 14860 | Submission Open

Keywords: critical care medicine; intensive care unit (icu); perioperative medicine; precision medicine; personalized therapy; hemodynamic monitoring; biomarkers; high-risk patients; organ support; artificial intelligence in critical care; sepsis; septic shock

(This special issue belongs to the Section Personalized Medical Care)

Dermatology: Diagnosis and Personalized Treatment

edited by Elisabeta Candrea and

Sorina Danescu

submission deadline 25 Jan 2026 | 1 articles | Viewed by 3749 | Submission Open

Keywords: biomarker; diagnostic tools; dermoscopy; ultrasound; confocal microscopy; therapeutic; personalized medicine

(This special issue belongs to the Section Mechanisms of Diseases)

Advances in the Use of Machine Learning for Personalized Medicine

edited by

Josip Vrdoljak

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2656 | Submission Open

Keywords: LLMs in medicine; machine learning; deep learning; drug discovery; personalized medicine

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Therapy for Psychophysical Health: An Integrative Approach

edited by

Giada Pietrabissa

and

Giada Rapelli

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1512 | Submission Open

Keywords: personalized therapy; patient-centered care; quality of life; psychosocial factors; adherence; self-management; multidisciplinary intervention; digital health tools

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Atrial Fibrillation: Toward Personalized Medicine

edited by

Vincenzo Mirco La Fazia

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1505 | Submission Open

Keywords: atrial fibrillation; personalized medicine; genetic predisposition; electroanatomical mapping; pulsed field ablation; genomics; substrate characterization; tailored ablation strategies

(This special issue belongs to the Section Mechanisms of Diseases)

Precision Medicine in Anesthesia and Pain

edited by Paramita Basu

submission deadline 25 Jan 2026 | Viewed by 439 | Submission Open

Keywords: Neuropeptide Y; chronic pain; NPY receptors; therapeutics; anesthesia; precision medicine

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Precision Medicine in Organ Transplantation: New Perspectives and Challenges

edited by

Tomasz Sta̧cel

submission deadline 25 Jan 2026 | Viewed by 414 | Submission Open

Keywords: organ transplantation; donor– recipient matching; immunosuppression strategies; transplant outcomes; diagnostics and perioperative care

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Dermatology

edited by

Liliana Gabriela Popa

and Calin Giurcaneanu

submission deadline 25 Jan 2026 | Viewed by 400 | Submission Open

Keywords: individualized treatment; dermatology; inflammatory skin diseases; bullous diseases; skin cancer; genodermatoses; chronic wounds

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Current Trends and Advances in Spondyloarthritis

edited by Francesca Bandinelli

submission deadline 30 Jan 2026 | 5 articles | Viewed by 25033 | Submission Open

Keywords: spondyloarthritis; ultrasound; MRI; HLA; gene; biomarkers; classification

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Recent Advances in Oral Diseases—2nd Edition

edited by

Omar Kujan

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4560 | Submission Open

Keywords: oral diseases; dental care; periodontal diseases; tooth loss; oral cancers; personalised dentistry

(This special issue belongs to the Section Epidemiology)

Advances in Infectious Disease Epidemiology

edited by Cesar Henriquez-Camacho

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4653 | Submission Open

Keywords: infectious diseases; epidemiology; genomics; machine learning; artificial intelligence; surveillance; vaccination; global health; stewardship programs

(This special issue belongs to the Section Epidemiology)

Sports Cardiology and Health Promotion Through Personalized Exercise Prescription

edited by

Luna Cavigli

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3169 | Submission Open

Keywords: sports cardiology; sports medicine; cardiomyopathies; personalized exercise prescription; cardiovascular prevention; cardiac rehabilitation; cardiopulmonary exercise test; cardiac imaging

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Otolaryngology: Big Data Application in Personalized Medicine

edited by

Herng-Ching Lin

and Yen-Fu Cheng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2606 | Submission Open

Keywords: otolaryngology; big data; epidemiology; precision medicine; personalized medicine; head and neck cancer

(This special issue belongs to the Section Omics/Informatics)

Musculoskeletal Diseases: Diagnosis, Rehabilitation and Personalized Treatment

edited by

Giacomo Farì

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2528 | Submission Open

Keywords: rehabilitation; regenerative medicine; telemedicine; musculoskeletal pain; sport; telemedicine; osteoarthritis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Precision Orthopedics: Evolving Shoulder, Hip, and Knee Surgery Through Intelligent Technology and Personalized Clinical Care

edited by Alessandra Berton

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2270 | Submission Open

Keywords: precision orthopedics; shoulder surgery; hip surgery; knee surgery; personalized medicine; artificial intelligence; robotic surgery; 3D printing; wearable sensors; patient outcomes

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Translational Research and Novel Therapeutics in Cutaneous Melanoma

edited by Maja Tolušić Levak and Martina Mihalj

submission deadline 31 Jan 2026 | Viewed by 410 | Submission Open

Keywords: cutaneus melanoma; immunopathology of melanoma; biomarkers; novel treatments; early diagnosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Current Clinical Practice and Future Trends of Oral and Maxillofacial Surgery

edited by Rocco Franco

submission deadline 31 Jan 2026 | Viewed by 241 | Submission Open

Keywords: oral and maxillofacial surgery; digital technology; regenerative medicine; artificial intelligence; personalized treatment.

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Systemic Sclerosis and Idiopathic Inflammatory Myopathies

edited by

Silvia Bellando Randone

and Lorenzo Cavagna

submission deadline 31 Jan 2026 | Viewed by 223 | Submission Open

Keywords: systemic sclerosis; idiopathic inflammatory myopathies; precision medicine; autoimmune diseases; biomarkers; genetic

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Immunotherapy and Targeted Therapy in Gynecologic Cancer: Current Status and Challenges

edited by Brigida Anna Maiorano and

Mauro Francesco Pio Maiorano

submission deadline 31 Jan 2026 | Viewed by 211 | Submission Open

Keywords: immunotherapy; targeted therapy; gynecologic cancer; vulvar cancer; biomarkers; immune checkpoint inhibitors; HPV-related tumors; personalized oncology

(This special issue belongs to the Section Molecular Targeted Therapy)

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