Protein Microarrays

Dear Colleagues,

With the rapid development of proteomics and translational medicine, there is an increasing demand for high-throughput studies on protein profiling, molecular function, drug screening, as well as finding biomarkers for the diagnostics and therapeutic treatment of a variety of human diseases.

In the last decade, protein microarrays have made significant inroads in their use in both basic and clinical research. With the state-of-the-art array technologies, thousands of proteins or antibodies can be displayed well on a microscopic surface using small amounts of sample. Proteome microarrays from different species have been produced, including human, bacterial pathogens, Arabidopsis and viruses, etc. Those protein microarrays have demonstrated the power of unbiased screening for the target of interest in different biological and clinical samples from proteomics scale, such as protein interactions, post-translational modifications, (auto) antibody biomarker and drug target identifications, etc. Already, the first proteomics-derived blood assay for early breast cancer detection, Videssa® Breast consisting of autoantibody and protein biomarkers, have been entered into the multi-center clinical validations (PMID: 20977275, PMID:27508384). Compared to high-density protein microarrays, bead-based arrays are good at quantifications with sandwich immunoassays and more frequently used in the validation of cancer biomarkers in a large cohort of clinical samples as well as in clinical diagnostics when the multiplexing is necessary, i.e., OVA1 test (ASPiRA LABSTM). This Special Issue of protein microarrays will be focus on the technologies and applications of protein microarrays from basic research to translational medicine. The manuscripts describing protein microarrays, antibody microarrays, reverse-phase protein arrays, peptide microarrays, lectin microarrays and bead-based arrays are welcome.

Prof. Xiaobo Yu
Prof. Joshua LaBaer
Guest Editors

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