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Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 1): Defect Patterns, Fixation Strategies and Reconstruction Options—A Review -
Advancements and Challenges in Tissue-Engineered Heart Valves: Integrating Biomechanics, Biomaterials, and Biomimetic Design for Functional Maturity -
Granular Jamming in Soft Robotics: Simulation Frameworks and Emerging Possibilities—Review
Journal Description
Biomimetics
Biomimetics
is an international, peer-reviewed, open access journal on biomimicry and bionics, published monthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, Ei Compendex, CAPlus / SciFinder, and other databases.
- Journal Rank: JCR - Q1 (Engineering, Multidisciplinary) / CiteScore - Q2 (Biomedical Engineering)
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 17 days after submission; acceptance to publication is undertaken in 3.8 days (median values for papers published in this journal in the second half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
3.9 (2024);
5-Year Impact Factor:
4.0 (2024)
Latest Articles
High-Dimensional Feature Selection Using Improved Hybrid Breeding Optimization Algorithm with Feature Grouping
Biomimetics 2026, 11(6), 406; https://doi.org/10.3390/biomimetics11060406 (registering DOI) - 8 Jun 2026
Abstract
Feature selection is essential for improving classification performance in high-dimensional biomedical data, yet conventional metaheuristic algorithms often suffer from premature convergence and loss of population diversity. To address these issues, this paper proposes a Feature Grouping and Improved Hybrid Breeding Optimization framework (FGIHBO).
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Feature selection is essential for improving classification performance in high-dimensional biomedical data, yet conventional metaheuristic algorithms often suffer from premature convergence and loss of population diversity. To address these issues, this paper proposes a Feature Grouping and Improved Hybrid Breeding Optimization framework (FGIHBO). First, the original feature space is hierarchically partitioned using the Maximum Relevance Minimum Redundancy criterion and Symmetric Uncertainty analysis to alleviate the curse of dimensionality. Then, a Multi-Strategy Synergistic Improved Hybrid Breeding Optimization (MSIHBO) algorithm is developed by incorporating Grey Wolf Optimizer (GWO) guidance and a Shannon entropy-adaptive simulated annealing mechanism to balance exploration and exploitation. Experimental results on the CEC2022 benchmark suite demonstrate that MSIHBO provides robust optimization performance across diverse problem categories. Furthermore, evaluations on eleven high-dimensional biomedical datasets show that FGIHBO achieves average classification accuracies ranging from 92.77% to 97.66%. Compared with representative algorithms, including Multi-strategy Improved Grey Wolf Optimizer (MIGWO), Hybrid Whale Optimization Algorithm based on Gathering strategy (HWOAG), Dynamic Crow Search Algorithm (DCSA), GWO, Hybrid Breeding Optimization (HBO), Hybrid Breeding Optimization based on Lévy flight and Elite Opposition-Based Learning strategy (LEHBO), and MSIHBO, the proposed framework improves average classification accuracy by 1.47–27.46%, with the largest gain observed on dataset D10 relative to HWOAG. These results confirm the effectiveness, robustness, and scalability of the proposed framework for high-dimensional biomedical feature selection.
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(This article belongs to the Section Biological Optimisation and Management)
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Open AccessArticle
Endogenous Circadian Rhythms in Plant Bioelectric Signals: Cross-Station Replication and Visitor-Driven Suppression in a Public Exhibition
by
Peter A. Gloor
Biomimetics 2026, 11(6), 405; https://doi.org/10.3390/biomimetics11060405 - 8 Jun 2026
Abstract
We report a cross-station replication of endogenous circadian rhythms in plant bioelectric voltage, recorded continuously for 42 days at three independent sensor stations within a public science exhibition (Phänomena, Dietikon, Switzerland; March–April 2026). Three primrose (Primula vulgaris) stations were equipped with
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We report a cross-station replication of endogenous circadian rhythms in plant bioelectric voltage, recorded continuously for 42 days at three independent sensor stations within a public science exhibition (Phänomena, Dietikon, Switzerland; March–April 2026). Three primrose (Primula vulgaris) stations were equipped with custom Biolingo bioelectric sensors (ESP32 + AD8232) and recorded autonomously through approximately 21,000 visitor interactions. We extracted DC-invariant spectral features from 5–10 s voltage windows (n = 78,431 quality-filtered files) and fitted two-stage cosinor models with bootstrap 95% confidence intervals. All three stations show a robust 24 h rhythm in the 1–5 Hz band power (bp1–5), with peak-to-trough amplitudes between 0.35× and 1.19× of mesor (R2med 0.72–0.87). Acrophase varies across stations from 05:00 to 11:00 local time. Critically, the rhythm survives an overnight-only restriction (18:00–09:00, no visitors) at all three stations, ruling out visitor presence as the rhythm driver. The most visitor-intensive station (faces of museum visitors triggering an emotion-recognition installation) additionally shows a sharp daytime amplitude collapse coincident with the exhibition opening at 09:00, during the hours of sustained visitor presence. This temporal coincidence is consistent with—though not by itself proof of—the cardiovascular-mechanosensory coupling characterized at single-subject resolution in a companion study. We argue that bp1–5—the spectral band most directly related to plant action-potential activity—carries an endogenous circadian signal in Primula vulgaris and that this station-level signal co-varies with sustained nearby human presence in a manner consistent with frequency-selective mechanosensory coupling, although the observational design cannot establish this mechanism. From a biomimetic perspective, this suggests that the plant’s evolved bioelectric sensing apparatus might be leveraged as a live ambient biosensor for nearby human activity, complementing the more common biomimetic approach of replicating plant sensing in synthetic devices.
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(This article belongs to the Special Issue 10th Anniversary of Biomimetics: Bioinspired Sensing, Information Processing and Intelligent Control)
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Open AccessArticle
High-Dimensional Small-Sample Feature Selection Using Co-Evolutionary Ant Colony Optimization Inspired by Heterosis
by
Chunli Xiang, Jing Zhou, Zhiwei Ye, Zenggang Xiong, An Song, Dingfeng Song and Jie Sun
Biomimetics 2026, 11(6), 404; https://doi.org/10.3390/biomimetics11060404 - 8 Jun 2026
Abstract
High-dimensional small-sample data are widely encountered in medical diagnosis, bioinformatics, and industrial inspection, where traditional feature selection methods often suffer from premature convergence and local optima. To address these issues, this paper proposes a Hybrid Breeding-based Co-evolutionary Ant Colony Optimization method (HBACO) for
[...] Read more.
High-dimensional small-sample data are widely encountered in medical diagnosis, bioinformatics, and industrial inspection, where traditional feature selection methods often suffer from premature convergence and local optima. To address these issues, this paper proposes a Hybrid Breeding-based Co-evolutionary Ant Colony Optimization method (HBACO) for feature selection. Inspired by the principle of hybrid breeding, in which individuals with distinct traits produce superior offspring through cross recombination, inheritance of desirable genes and continuous evolution, the proposed algorithm establishes a three-population collaborative framework. It consists of an ACO-based search population, an HRO-based evolutionary population and a cooperative feedback population that evolve iteratively together. Furthermore, we devise a heuristic strategy integrating correlation and genetic characteristics to help mine high-value feature subsets. Meanwhile, a collaborative pheromone updating mechanism is adopted to realize efficient knowledge sharing among populations. Experiments conducted on 13 high-dimensional datasets, including Colon and Lung, demonstrate that HBACO achieves superior classification accuracy, feature reduction performance, and convergence behavior compared with 10 representative algorithms. Specifically, HBACO improves the average classification accuracy by 3.9% and achieves an average feature dimensionality reduction rate of 91.4%. Statistical tests further confirm the significance of the proposed method. The results indicate that HBACO provides an effective and robust solution for high-dimensional feature selection problems.
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(This article belongs to the Section Biological Optimisation and Management)
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Open AccessReview
Calcium Hypophosphite: A New Active Ingredient for Biomimetic Oral Care
by
Joachim Enax, Pascal Fandrich, Erik Schulze zur Wiesche and Bennett T. Amaechi
Biomimetics 2026, 11(6), 403; https://doi.org/10.3390/biomimetics11060403 - 8 Jun 2026
Abstract
Hypophosphites (also known as phosphinates) are the salts of hypophosphorous acid (also known as phosphinic acid), H3PO2. Various hypophosphite salts are known such as calcium hypophosphite (Ca(H2PO2)2) and sodium hypophosphite (Na(H2PO
[...] Read more.
Hypophosphites (also known as phosphinates) are the salts of hypophosphorous acid (also known as phosphinic acid), H3PO2. Various hypophosphite salts are known such as calcium hypophosphite (Ca(H2PO2)2) and sodium hypophosphite (Na(H2PO2)). Hypophosphites were proposed as a potential treatment for tuberculosis as early as the 1850s; however, they were found to be ineffective against this disease. Following this, there was a period of around 100 years during which no new studies on hypophosphites were published. Subsequent in vitro studies have shown that hypophosphites can be used as potential antibacterial food preservatives. Currently, calcium hypophosphite is used in commercial food supplements for children, as this compound is a suitable source of calcium ions. It also has other advantageous properties, including exceptionally high water solubility (154 g/L at 25 °C), a neutral taste, a high mass fraction of calcium per molecule (23.6%), and an excellent safety profile. Recent studies have shown its potential as an active ingredient in the field of oral care. Since biological mechanisms such as tooth and bone formation and natural remineralization due to saliva rely on calcium ions, calcium hypophosphite can be regarded as a biomimetic agent. Upon contact with phosphate from saliva, calcium hypophosphite forms hydroxyapatite; this imitation of physiological mineralization and crystallization processes in the human body further underlines its biomimetic character. This review summarizes and discusses the available literature on hypophosphites in human health and related fields.
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(This article belongs to the Special Issue Advances in Biomaterials, Biocomposites and Biopolymers 2026)
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Sustainable Design Reuse: Integrating Biomimicry and Parametric Thinking in Architectural Education
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Anis Semlali, Sana Tamzini and Liudmila Cazacova
Biomimetics 2026, 11(6), 402; https://doi.org/10.3390/biomimetics11060402 - 8 Jun 2026
Abstract
Sustainability challenges in the built environment demand a shift in architectural education from form-based approaches toward adaptive, systems-oriented, and performance-driven thinking. This paper examines an integrated pedagogical model combining biomimicry, parametric thinking, and modular design to enhance sustainable design learning in architectural studios.
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Sustainability challenges in the built environment demand a shift in architectural education from form-based approaches toward adaptive, systems-oriented, and performance-driven thinking. This paper examines an integrated pedagogical model combining biomimicry, parametric thinking, and modular design to enhance sustainable design learning in architectural studios. Using a qualitative case study approach, this research investigates Architectural Design Studio 4 at the American University of Ras Al Khaimah (AURAK), where third-year students followed a three-stage discovery-based process. Students first analyzed biological systems to identify transferable principles, then translated these principles into parametric modules using computational tools such as Dynamo and Revit, and finally applied the systems to high-rise architectural design. The findings indicate that integrating biomimicry with parametric workflows encouraged optimization, adaptability, and reusable design strategies rather than fixed outcomes. Modular design approaches helped students manage architectural complexity, while computational tools supported performance-based exploration and informed decision-making. The absence of a predetermined final design fostered critical thinking, creativity, and problem-solving skills. This study contributes empirical evidence to architectural education research by demonstrating that process-based, discovery-oriented studios can strengthen students’ understanding of sustainability, systems logic, and adaptability, preparing future architects for contemporary environmental and technological challenges.
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(This article belongs to the Special Issue Advances in Computational Methods for Biomechanics and Biomimetics)
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Open AccessArticle
Lightweight Low-Light Enhancement Network with Multi-Bio-Inspired Visual Mechanisms
by
Yafeng Zhao, Xiang Li, Shuaipeng Hao, Min Yu, Yanli Gao and Shiwei Fan
Biomimetics 2026, 11(6), 401; https://doi.org/10.3390/biomimetics11060401 - 7 Jun 2026
Abstract
In edge deployment scenarios, low-light image enhancement faces a trade-off between model complexity and perceptual quality, limiting lightweight models under resource constraints. To address this problem, this paper proposes a perceptual quality optimization model inspired by biological visual mechanisms. Specifically, a GT-Mean loss
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In edge deployment scenarios, low-light image enhancement faces a trade-off between model complexity and perceptual quality, limiting lightweight models under resource constraints. To address this problem, this paper proposes a perceptual quality optimization model inspired by biological visual mechanisms. Specifically, a GT-Mean loss is introduced to simulate the luminance adaptation property of the mammalian retina, effectively mitigating optimization bias caused by exposure inconsistency in imaging sensors, while the LPIPS loss, aligned with the perceptual preferences of the human visual system (HVS), is incorporated to enhance subjective visual quality. From a structural perspective, inspired by the multi-scale perception of insect compound eyes, biologically selective attention, and color constancy mechanisms, the proposed model integrates an efficient texture-aware attention module, an enhanced multi-scale feature fusion strategy, and a chrominance denoising module. Experimental results demonstrate that, while maintaining an extremely low parameter count of only 0.52 M, the proposed model consistently outperforms existing lightweight methods on the LOL series datasets in terms of PSNR, SSIM, and LPIPS. This work provides an efficient perceptual quality optimization solution for bioinspired visual sensing under resource-constrained conditions.
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(This article belongs to the Special Issue Bionic Vision Applications and Validation)
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A Two-Stage PPO–RLMPA Framework for Dynamic Economic Dispatch with Renewable Energy and Storage Integration
by
Kemal Keskin
Biomimetics 2026, 11(6), 400; https://doi.org/10.3390/biomimetics11060400 - 6 Jun 2026
Abstract
The Dynamic Economic Dispatch (DED) problem underpins the cost-efficient and reliable operation of modern power systems, yet valve-point loading, ramp-rate coupling, and the growing share of intermittent wind, photovoltaic, and pumped-storage hydro (PSH) resources render it highly non-convex. Metaheuristic methods typically require large
[...] Read more.
The Dynamic Economic Dispatch (DED) problem underpins the cost-efficient and reliable operation of modern power systems, yet valve-point loading, ramp-rate coupling, and the growing share of intermittent wind, photovoltaic, and pumped-storage hydro (PSH) resources render it highly non-convex. Metaheuristic methods typically require large computational budgets and hand-crafted constraint-handling rules, whereas deep reinforcement learning agents rarely guarantee the feasibility of the schedules they produce. To address both limitations, this paper proposes a Two-Stage PPO–RLMPA framework that couples data-driven policy learning with a biomimetic metaheuristic search inspired by marine predator–prey dynamics. In the first stage, a Proximal Policy Optimization (PPO) agent is trained on a Markov Decision Process reformulation of DED in which a deterministic Safety Layer projects every raw action onto the feasible set defined by capacity, ramp-rate, and power-balance constraints, so the policy only observes physically viable transitions. In the second stage, the PPO dispatch is refined by the RLMPA module, a Marine Predators Algorithm (MPA) whose exploration–exploitation balance, Lévy-flight foraging, and Fish Aggregating Devices (FADs) attraction mechanisms emulate strategies documented in marine ecosystems; its step-size factor and FADs probability are further adapted online by a Deep Q-Network. This biomimetics-informed refinement translates predator–prey foraging intelligence into economically efficient thermal dispatch under valve-point non-convexity. Across 30 independent runs on ten- and twenty-unit benchmark systems with wind, PV, and PSH integration, the framework attains best costs of USD 368,763 and USD 737,348 on Test Systems 1 and 2, corresponding to reductions of approximately and over the CFCEP baseline, with zero post-repair constraint violations in every run.
Full article
(This article belongs to the Special Issue Nature-Inspired Sustainable Engineering)
Open AccessReview
Artificial Muscles: Electrostatic Actuation and Design Tradeoffs
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Gabriel X. Colborn, Justin Pilgrim, Ka Ho, Pragya Natarajan, Arnia Goode, Jeffrey K. Catterlin, Michael Krause, Terak Hornik and Emil P. Kartalov
Biomimetics 2026, 11(6), 399; https://doi.org/10.3390/biomimetics11060399 - 5 Jun 2026
Abstract
Artificial muscles are an emerging class of actuators designed to mimic the compliant, efficient, and versatile behavior of biological muscles for fields including the following: soft robotics, prosthetics, wearable enhancements, haptic interfaces, and biomedical devices. These systems encompass various actuation mechanisms, including pneumatic,
[...] Read more.
Artificial muscles are an emerging class of actuators designed to mimic the compliant, efficient, and versatile behavior of biological muscles for fields including the following: soft robotics, prosthetics, wearable enhancements, haptic interfaces, and biomedical devices. These systems encompass various actuation mechanisms, including pneumatic, hydraulic, thermal, ionic, electrochemical, and electrostatic. Each with distinct tradeoffs in voltage, strain, output force, bandwidth, efficiency, and manufacturability. Among them, electrostatic actuators have attracted increased attention due to their fast response times, high energy densities, strong compatibility with soft materials, and scalability from microscale devices to large-area and stacked actuators. However, challenges such as dielectric breakdown, material fatigue, and fabrication complexity continue to limit widespread deployment. This review presents a structured classification of various artificial muscle technologies and an in-depth examination of electrostatic actuators including dielectric elastomers, electrostrictive and ferroelectric polymers, liquid crystal elastomers, electrostatic film motors, stacked architectures, and microscale/milliscale devices. In this review the operating principles, materials, architectures, performance characteristics, and failure modes of electrostatic actuators will be discussed. Additionally, a comparison will highlight tradeoffs across actuator families based on metrics such as voltage, force, strain, bandwidth, and manufacturability. Lastly, we outline future research directions in materials, physics-informed modeling, system integration, and scalable fabrication necessary to advance electrostatic artificial muscles toward practical, real-world deployment.
Full article
(This article belongs to the Special Issue Sustainable Soft Robotics: Innovations and Advances in Soft Manipulators and Grippers 2026)
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Unsteady Aerodynamics in Bio-Inspired Flapping Wings for Low-Density Environments
by
Emilia Georgiana Prisăcariu, Oana Dumitrescu, Mihail Sima, Vlad Aparece-Scutariu, Sergiu Strătilă, Raluca Andreea Roșu, Cleopatra Cuciumita, Iulian Vlăducă and Silvia Bica
Biomimetics 2026, 11(6), 398; https://doi.org/10.3390/biomimetics11060398 - 5 Jun 2026
Abstract
Flapping-wing flight offers a promising solution for aerial mobility in low-density environments such as the Martian atmosphere, where conventional rotorcraft faces significant performance constraints. However, the coupled aerodynamic and structural mechanisms governing lift generation at low Reynolds numbers remain insufficiently understood. This study
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Flapping-wing flight offers a promising solution for aerial mobility in low-density environments such as the Martian atmosphere, where conventional rotorcraft faces significant performance constraints. However, the coupled aerodynamic and structural mechanisms governing lift generation at low Reynolds numbers remain insufficiently understood. This study investigates the aeroelastic and unsteady aerodynamic behaviour of a bio-inspired flapping wing using an integrated experimental–numerical framework. High-speed imaging is employed to extract representative wing kinematics, including flapping frequency, stroke amplitude, and rotational motion. A geometrically scaled wing model is developed based on Reynolds number similitude and analysed using finite element methods to characterise its dynamic response. Aeroelastic behaviour is evaluated through modal transient simulations, while aerodynamic performance is assessed using both vortex-lattice modelling and computational fluid dynamics. The results show strong coupling between bending and torsional modes, with the structural response highly dependent on excitation frequency relative to the natural modes. Near-resonant conditions lead to amplified deformation and distinct phase relationships, while aerodynamic simulations reveal vortex-dominated lift generation. These findings provide a physics-based framework for the design and analysis of flapping-wing systems operating in low-Reynolds-number and low-density flight regimes.
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(This article belongs to the Special Issue Bio-Inspired Modes of Flight)
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A Hybrid Nonlinear Greater Cane Rat Algorithm with Teaching–Learning-Based Optimization for Global Optimization and Constrained Engineering Applications
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Jinzhong Zhang, Hongkai Li, Tan Zhang and Zhen He
Biomimetics 2026, 11(6), 397; https://doi.org/10.3390/biomimetics11060397 - 4 Jun 2026
Abstract
The greater cane rat algorithm (GCRA) represents an emerging swarm intelligence paradigm derived from the instinctual survival patterns exhibited by greater cane rats (GCRs), which simulates the typical male-dominated survival patterns of the GCR species, including rainy-season mating and reproduction behaviors, dry-season behavioral
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The greater cane rat algorithm (GCRA) represents an emerging swarm intelligence paradigm derived from the instinctual survival patterns exhibited by greater cane rats (GCRs), which simulates the typical male-dominated survival patterns of the GCR species, including rainy-season mating and reproduction behaviors, dry-season behavioral differentiation of solitary males and clustered females, and their nonlinear adaptive foraging characteristics. Nevertheless, the original GCRA suffers from inherent defects in complex and high-dimensional optimization scenarios, encompassing premature convergence phenomena, inadequate local exploitation proficiency, constrained convergence precision, and a proneness to stagnation at local optima, which severely restrict its practical engineering application. To address the aforementioned limitations, this work introduces an enhanced hybrid variant of the greater cane rat algorithm, amalgamated with Teaching-and-Learning-Based Optimization (TLBO) and designated as the TLGCRA, incorporating three pivotal targeted innovations. Specifically, the TLGCRA innovatively introduces the two-stage teacher–student interactive learning mechanism of TLBO on the basis of retaining the core evolutionary and behavioral characteristics of the original GCRA, which effectively compensates for the insufficient local disturbance capability of the original algorithm and enriches population diversity to avoid local optimum stagnation. Furthermore, an adaptive parameter tuning strategy is innovatively designed and embedded in the iterative optimization process, which dynamically balances the global exploration and local exploitation capabilities of the algorithm, fundamentally improving the low learning efficiency and weak mining performance of the GCRA. A suite of computational simulations is conducted across 23 canonical benchmark functions and six representative constrained engineering design optimization scenarios. The introduced TLGCRA is benchmarked against the canonical GCRA, LPSO, and ten cutting-edge metaheuristic approaches. Empirical outcomes substantiate that the TLGCRA attains marked performance advantages in terms of convergence velocity, solution precision, and algorithmic resilience. In particular, the optimized design effectively improves the optimal solution precision of the algorithm in complex multimodal function optimization, and the standard deviation of multiple independent runs in six engineering application cases is close to zero, verifying its excellent stability. Statistical verification employing the Friedman test and Wilcoxon signed-rank test additionally corroborates that the TLGCRA exhibits statistically robust and dependable optimization efficacy. In summary, the proposed innovative fusion strategies endow the TLGCRA with stronger environmental adaptability and comprehensive optimization performance, enabling it to realize faster convergence speed and higher computational accuracy, as well as outstanding stability and robustness, thus furnishing a viable resolution framework for intricate constrained engineering optimization challenges.
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(This article belongs to the Section Biological Optimisation and Management)
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Multiscale Modeling and Analysis of Muscle Tissue: A Finite Element Approach for 3D Braided Composite Structures
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Vivek Kumar Dhimole, Niraj Kumar, Seul-Yi Lee and Soo-Jin Park
Biomimetics 2026, 11(6), 396; https://doi.org/10.3390/biomimetics11060396 - 4 Jun 2026
Abstract
Skeletal muscle mechanics arise from hierarchical fiber–matrix interactions spanning multiple length scales. This study presents a computationally efficient, composite-inspired multiscale finite element framework that links muscle microstructure to whole-muscle behavior through explicit periodic numerical homogenization. Muscle fibers and endomysium are resolved at the
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Skeletal muscle mechanics arise from hierarchical fiber–matrix interactions spanning multiple length scales. This study presents a computationally efficient, composite-inspired multiscale finite element framework that links muscle microstructure to whole-muscle behavior through explicit periodic numerical homogenization. Muscle fibers and endomysium are resolved at the microscale, their homogenized response is propagated to fascicles embedded in the perimysium at the mesoscale, and the resulting properties are incorporated into a three-dimensional macroscale muscle model including the epimysium. Unlike phenomenological continuum models or computationally intensive chemo-electro-mechanical approaches, the proposed framework enables scalable three-dimensional simulations while preserving microstructural load-transfer mechanisms. The predicted stress–strain relationships in uniaxial tensile loading were in agreement with experimental values, with differences of about 1–3%. Passive elasticity of muscle is simulated in the present research in order to provide the computation model as a benchmark in further development into the active contraction and the viscoelastic behavior. Additionally, it provides a modeling basis for patient-specific studies under varied pathological conditions.
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(This article belongs to the Special Issue Advances in Bio-Inspired Design and Characterization of 3D-Printed Multimaterial Composites and Heterogeneous Structures)
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Hybrid Decision-Making Management for Material Selection in the Design of Wearable Pressure-Sensing Orthoses in Neurorehabilitation
by
Liliana-Laura Bădiță-Voicu, Roxana-Mariana Nechita, Adrian-Cătălin Voicu, Marius-Ionel Anton, Dana-Corina Deselnicu, Corina-Ionela Dumitrescu and Cristian Radu Badea
Biomimetics 2026, 11(6), 395; https://doi.org/10.3390/biomimetics11060395 - 4 Jun 2026
Abstract
Wearable pressure-sensing orthoses are increasingly used in neurorehabilitation to support gait recovery, monitor plantar pressure distribution, and improve patient mobility during repetitive therapy sessions. The performance of these devices depends strongly on the materials used in the skin-contact layer, since material properties influence
[...] Read more.
Wearable pressure-sensing orthoses are increasingly used in neurorehabilitation to support gait recovery, monitor plantar pressure distribution, and improve patient mobility during repetitive therapy sessions. The performance of these devices depends strongly on the materials used in the skin-contact layer, since material properties influence comfort, flexibility, durability, and force transmission during daily use. This study proposes a hybrid multi-criteria decision-making framework based on the Analytic Hierarchy Process (AHP) and the VIKOR method for material selection in sensor-integrated plantar orthoses. Five candidate materials, ethylene vinyl acetate (EVA), polyethylene (PE), polyurethane (PU), cobalt–chromium–molybdenum alloy (CoCrMo), and polypropylene (PP), were evaluated using five criteria: comfort and skin compatibility, elasticity, fatigue resistance, density, and energy dissipation. AHP was applied to determine the relative importance of the evaluation criteria using expert judgment, while VIKOR was used to rank the material alternatives and identify the compromise solution. The results showed that polyurethane achieved the best overall performance due to its balanced behavior in comfort, elasticity, and fatigue resistance, which are essential properties for long-term wearable neurorehabilitation devices. A sensitivity analysis confirmed that moderate variations in expert weighting did not modify the final ranking. Compared with conventional selection approaches based mainly on isolated material properties, the proposed framework offers a clear and reproducible method for integrating mechanical and user-related requirements into the material selection process for wearable orthoses.
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(This article belongs to the Section Biomimetic Design, Constructions and Devices)
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Open AccessArticle
The Development of a Syringe-Based Insulin Applicator Using a Biodesign-Based Methodology
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Alejandro A. Salinas-Aguilar, Sebastian Arriaga-Marin, Carlos A. Perez-Ramirez, Ignacio Cervantes-Gutierrez, Irving A. Cruz-Albarran, Andres Emilio Hurtado-Perez and Manuel Toledano-Ayala
Biomimetics 2026, 11(6), 394; https://doi.org/10.3390/biomimetics11060394 - 3 Jun 2026
Abstract
Effective diabetes management heavily relies on appropriate insulin administration, which strongly depends on the correct administration strategy. In this sense, insulin administration plays a fundamental role, as its use depends on the patient’s clinical condition and diabetes type. Traditional syringe-based methods require proper
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Effective diabetes management heavily relies on appropriate insulin administration, which strongly depends on the correct administration strategy. In this sense, insulin administration plays a fundamental role, as its use depends on the patient’s clinical condition and diabetes type. Traditional syringe-based methods require proper training to ensure that insulin is successfully delivered into the subcutaneous tissue, where it can be absorbed and metabolized; however, it is desirable to develop an insulin applicator that does not require training for its appropriate use. Aiming to provide support solutions that help patients to develop a correct administration technique, a biodesign-based methodology, coupled with biomimetic concepts, is employed to design a device that assists the user in creating a stable skin fold and guiding needle orientation during injection without requiring exhaustive training for device usage. A three-step approach is employed for the design, where computational fluid dynamics (CFD) and finite element analysis (FEA) methods are employed to ensure that the device produces a laminar insulin flow and the device strength is tested. It should be pointed out both methods are required since complications produced by sudden flows must be avoided, with CFD allowing assessment of the device mechanical properties in terms of the device strength. Initial functional evaluation indicates that the proposed approach does not require extensive training or complex operational procedures, facilitating its integration into everyday use. The device design is validated from the results obtained for the CFD analysis, as no turbulent flow is produced, whereas the FEA indicates that the geometrical form can handle the stresses produced by the folding generation without generating excessive deformations. Moreover, an infrared thermography analysis is also carried out to find out if the folding force generation is located in the zone of interest, the results of which indicate that the device operates in the desired physical zone.
Full article
(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition)
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Non-Parametric Kinematic Optimization of Flapping Foil Propulsion Using a Discrete Adjoint Method
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Zhaoran Yin, Chao Zhou, Xiaofei Wang, Xiaocun Liao and Jian Wang
Biomimetics 2026, 11(6), 393; https://doi.org/10.3390/biomimetics11060393 - 3 Jun 2026
Abstract
Optimizing flapping-foil kinematics for underwater propulsion is challenging due to strong temporal coupling and nonlinear fluid–structure interactions. Most existing approaches rely on parameterized motion profiles, which restrict the accessible design space. A non-parametric kinematic optimization framework based on the discrete adjoint method is
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Optimizing flapping-foil kinematics for underwater propulsion is challenging due to strong temporal coupling and nonlinear fluid–structure interactions. Most existing approaches rely on parameterized motion profiles, which restrict the accessible design space. A non-parametric kinematic optimization framework based on the discrete adjoint method is developed, enabling direct optimization of time-resolved motions without predefined functional forms. A Morison-based low-order hydrodynamic model, calibrated against Computational Fluid Dynamics (CFD), is employed for efficient evaluation within a validated regime. Results show that optimized motions substantially enhance propulsion performance over conventional sinusoidal motions, yielding non-sinusoidal, high-efficiency kinematics. In thrust-maximization cases, the optimized kinematics achieve a 50.29% increase in mean thrust by redistributing heave and pitch amplitudes and timing. Under balanced thrust–power conditions, the optimized motions consistently outperform sinusoidal counterparts. In power-minimization cases, a “generator-like” regime emerges, indicating a reversal of net energy transfer enabled by the non-parametric formulation. These results demonstrate that non-parametric optimization provides enhanced design flexibility and improved propulsion performance, offering a practical framework for biomimetic underwater propulsion design.
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(This article belongs to the Special Issue Bionic Robotic Fish: 3rd Edition)
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Fog Task Scheduling Using Quality-Source-Driven Multi-Anchor Synchronized Search Algorithm
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Haitao Xie, Zhuo Luo, Zhiwei Ye, Wen Zhou, Xianjing Zhou, Donglei Xu and Mingming Zhao
Biomimetics 2026, 11(6), 392; https://doi.org/10.3390/biomimetics11060392 - 3 Jun 2026
Abstract
Efficient task scheduling in heterogeneous IoT–Fog environments is challenging due to limited fog resources, diverse task demands, and conflicting QoS objectives. This paper proposes ASQS, a Quality-Source-driven Multi-Anchor Synchronized Search algorithm for IoT–Fog task scheduling. ASQS is biomimetically motivated by collective search behaviors
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Efficient task scheduling in heterogeneous IoT–Fog environments is challenging due to limited fog resources, diverse task demands, and conflicting QoS objectives. This paper proposes ASQS, a Quality-Source-driven Multi-Anchor Synchronized Search algorithm for IoT–Fog task scheduling. ASQS is biomimetically motivated by collective search behaviors in natural systems, where distributed exploration, collective memory, and probabilistic cooperation support an exploration–exploitation balance. Specifically, ASQS constructs quality layers from candidate schedules, extracts representative quality-source anchors, and reuses them through an ACO-inspired probabilistic synchronization mechanism, thereby improving the utilization of high-quality historical search information. FNO-based search and Lévy-flight perturbation are further incorporated to enhance directional guidance and long-range exploration. Experiments on 33 benchmark functions, ablation studies, sensitivity analysis, standard fog scheduling scenarios, and large-scale task-intensive scenarios were conducted to evaluate ASQS. The results show that ASQS achieves competitive optimization accuracy, stable convergence, and superior comprehensive scheduling performance in terms of fitness, makespan, latency, load balance, and constraint handling. In particular, the large-scale experiment with 100 fog nodes and up to 8000 IoT tasks verifies the scalability of ASQS under heavy workload pressure. Statistical tests further confirm the reliability of the observed improvements. These results demonstrate that ASQS is an effective, scalable, and biomimetically motivated optimizer for IoT–Fog task scheduling.
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(This article belongs to the Section Biological Optimisation and Management)
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Open AccessArticle
A Multi-Segmented Vectoring Nozzle Configuration Inspired by the Mating Wheel of Damselfly
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Bolin Liu, Linyang Chai, Chao Tian, Hengbo Chen, Huan Shen, Qian Qi, Jilei Fan, Chufei Tang and Aihong Ji
Biomimetics 2026, 11(6), 391; https://doi.org/10.3390/biomimetics11060391 - 2 Jun 2026
Abstract
Conventional thrust vector control nozzles are severely constrained by a single-pivot deflection paradigm, which induces asymmetric shock reflections and adverse boundary layer separation at large angles. Multi-segmented serial configurations offer a promising alternative to overcome these limitations by distributing the total deflection across
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Conventional thrust vector control nozzles are severely constrained by a single-pivot deflection paradigm, which induces asymmetric shock reflections and adverse boundary layer separation at large angles. Multi-segmented serial configurations offer a promising alternative to overcome these limitations by distributing the total deflection across multiple joint interfaces, thereby achieving large terminal angles and smooth flow-path curvatures. To realize such a configuration, this study draws inspiration from the abdominal bending mechanism of the damselfly Ischnura elegans during mating wheel formation. Real-time video recording and morphological characterizations identified abdominal segments VI and VII as critical for high-amplitude bending under load. Finite element analysis under muscular actuation elucidated the biomechanical synergy, which was rigorously verified through mesh convergence and material property sensitivity checks. Inspired by this biological system, a multi-segmented nozzle configuration incorporating discrete elastic elements and a centralized cable-driven layout was designed and evaluated using multibody dynamics and computational fluid dynamics. The nozzle achieved a continuous 61.20° deflection within 8 s under subsonic exhaust conditions, successfully stabilizing periodic supersonic shock structures and completely suppressing adverse boundary layer separation. These findings turn biological bending into a thrust vectoring method, giving insights for next-generation agile aerospace propulsion systems.
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(This article belongs to the Special Issue Bioinspired Engineered Systems: 2nd Edition)
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Fitness Distance Balanced Starfish Optimization for Benchmark and Engineering Design Problems
by
Tuğrul Yağbasan, Ömür Akyazı, Hayati Türe and Bekir Dizdaroğlu
Biomimetics 2026, 11(6), 390; https://doi.org/10.3390/biomimetics11060390 - 2 Jun 2026
Abstract
Biomimetic optimizers are increasingly used to solve complex engineering problems, yet their performance depends strongly on how effectively they preserve diversity while maintaining selection pressure toward promising regions. In this study, the Starfish Optimization Algorithm (SFOA) is enhanced through fitness–distance-aware selection control, leading
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Biomimetic optimizers are increasingly used to solve complex engineering problems, yet their performance depends strongly on how effectively they preserve diversity while maintaining selection pressure toward promising regions. In this study, the Starfish Optimization Algorithm (SFOA) is enhanced through fitness–distance-aware selection control, leading to two improved variants: Fitness–Distance Balance Starfish Optimization Algorithm (FDBSFOA) and Dynamic Fitness–Distance Balance Starfish Optimization Algorithm (dFDBSFOA). The proposed framework guides candidate selection using both solution quality and spatial diversity relative to the current best solution, while the dynamic variant further adapts this balance over the course of the search to improve exploration in early iterations and exploitation near convergence. The proposed methods are evaluated on the IEEE CEC2017, CEC2020, and CEC2022 benchmark suites under a unified maximum function evaluation budget, MaxFEs = 10,000 × D, with 21 independent runs, and are further validated on constrained engineering design problems. Performance is assessed using convergence behavior, robustness indicators, computational overhead, and nonparametric statistical tests. The results show that the proposed variants improve the robustness and search efficiency of baseline SFOA, with dFDBSFOA providing the most consistent overall performance while introducing a controlled and interpretable computational overhead. These findings suggest that diversity-aware selection can serve as an effective design principle for strengthening biomimetic optimization frameworks. The current study focuses mainly on continuous, single-objective, and stationary benchmark problems, while the engineering-design validation also includes constrained and discrete/integer-coded cases. Extending the proposed strategy to dynamic, noisy, large-scale mixed-integer, or multi-objective settings remains future work.
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(This article belongs to the Special Issue Application of Nature-Inspired Algorithms and Technologies in Engineering)
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Reverse Mutation for Optimization Learning Artificial Lemming Algorithm and Its Application in Engineering
by
Mingbin Tang, Yejun Zheng, Lianbao Li, Li Cao and Zihao Cheng
Biomimetics 2026, 11(6), 389; https://doi.org/10.3390/biomimetics11060389 - 2 Jun 2026
Abstract
Complex engineering optimization problems often exhibit high-dimensional, multi-constraint, and nonlinear characteristics. Traditional deterministic optimization methods rely on gradient information and have limited optimization ranges, making it difficult to meet the requirements of efficient and accurate solutions. Intelligent optimization algorithms have become the core
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Complex engineering optimization problems often exhibit high-dimensional, multi-constraint, and nonlinear characteristics. Traditional deterministic optimization methods rely on gradient information and have limited optimization ranges, making it difficult to meet the requirements of efficient and accurate solutions. Intelligent optimization algorithms have become the core means of solving such problems. Aiming at the limitations of the standard artificial lemming algorithm (ALA), such as insufficient population diversity, premature convergence, weak local exploitation ability, and slow convergence speed, which make it difficult to meet the requirements of solving complex engineering optimization problems, this paper proposes a reverse mutation for optimization learning artificial lemming algorithm (RMALA). Based on the ALA algorithm, the algorithm integrates three strategies: Cauchy mutation, the improved salp swarm algorithm (ISSA), and reverse mutation for optimization learning. The Cauchy mutation is used to maintain population diversity and avoid premature convergence of the algorithm. The improved salp swarm algorithm enhances the local exploitation ability of the algorithm and improves the optimization accuracy. Reverse mutation for optimization learning guides the population toward the global optimal solution region and accelerates the convergence speed. The significant experimental results show that in the CEC2017 and CEC2022 standard test sets, as well as the three classic engineering constrained optimization problems of welded beams, cantilever beams, and pressure vessels, RMALA’s optimization accuracy is improved by more than 30% compared to the original ALA, and its convergence speed is improved by more than 25%. Its stability and robustness are better than those of five new swarm intelligence algorithms proposed in recent years. It can efficiently solve complex high-dimensional, nonlinear constrained optimization problems and has high significant engineering application value and academic innovation.
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(This article belongs to the Special Issue Advances in Biological and Bio-Inspired Algorithms: 2nd Edition)
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Bio-Inspired Photocatalytic Degradation of Humic Acids over TiO2- and Ag-Doped TiO2-Functionalized Clinoptilolite: Mechanistic Insights into Nature-Mimicking Oxidation Pathways
by
Liliana Bobirică, Cristina Modrogan, Constantin Bobirică and Oanamari Daniela Orbuleţ
Biomimetics 2026, 11(6), 388; https://doi.org/10.3390/biomimetics11060388 - 2 Jun 2026
Abstract
This study investigates the bio-inspired photocatalytic degradation of humic acids using TiO2-functionalized clinoptilolite (C–TiO2) and Ag-doped TiO2 (C–TiO2/Ag) under UV irradiation. TiO2 acts as an artificial analogue of naturally occurring photoactive mineral phases, while clinoptilolite
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This study investigates the bio-inspired photocatalytic degradation of humic acids using TiO2-functionalized clinoptilolite (C–TiO2) and Ag-doped TiO2 (C–TiO2/Ag) under UV irradiation. TiO2 acts as an artificial analogue of naturally occurring photoactive mineral phases, while clinoptilolite provides a biomimetic scaffold mimicking mineral–organic interfaces. Ag doping enhances charge separation and promotes reactive oxygen species formation, accelerating degradation. The effects of pH and catalyst composition were evaluated over a range of conditions, including the native pH of the humic solution. Degradation was monitored via changes in UV254 absorbance, VIS436 absorbance, and COD values, revealing a multistage pathway: rapid decolorization of chromophoric groups, slower breakdown of aromatic structures, and final mineralization. Acidic conditions further enhanced performance through increased adsorption and ROS (reactive oxygen species) generation, while measurable activity persisted at near-natural pH values. Kinetic analysis indicated pseudo-first-order behavior, with the highest apparent rate constants obtained for VIS436 removal under C–TiO2/Ag at pH 3 (k = 0.0166 min−1), followed by COD1 (k = 0.0190 min−1), confirming faster oxidation of labile fractions and slower mineralization of recalcitrant intermediates. Therefore, the results demonstrate that semiconductor–mineral hybrid systems can serve as biomimetic platforms that reproduce and accelerate natural self-purification processes, providing mechanistic insights into nature-inspired pathways for water treatment.
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(This article belongs to the Special Issue Advances in Biogenic and Biomimetic Materials: From Bionanomedicine to Environmental Applications and Beyond: 2nd Edition)
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Hybrid Nature-Inspired Optimization for the Cell Formation Problem with Machine Reliability and Alternative Routings
by
Paulo Figueroa-Torrez, Broderick Crawford, Orlando Durán, Martín Jurado-Camacho, Dayana Roxana Andrade Roque, Adrian Vargas-Gutierrez and Felipe Cisternas-Caneo
Biomimetics 2026, 11(6), 387; https://doi.org/10.3390/biomimetics11060387 - 1 Jun 2026
Abstract
The Cell Formation Problem plays a fundamental role in cellular manufacturing due to its impact on efficiency, flexibility, and reliability. Its complexity increases under real-world conditions involving alternative process routes and machine reliability constraints, leading to the Generalized Cell Formation Problem with machine
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The Cell Formation Problem plays a fundamental role in cellular manufacturing due to its impact on efficiency, flexibility, and reliability. Its complexity increases under real-world conditions involving alternative process routes and machine reliability constraints, leading to the Generalized Cell Formation Problem with machine reliability. Researchers have classified the Cell Formation Problem as an NP-Hard problem. To address this computational complexity, this study presents a comparative and hybrid evaluation of the Black Widow Optimizer and the Golden Eagle Optimizer for the Generalized Cell Formation Problem with machine reliability, examining whether mechanisms derived from the Black Widow Optimizer can enhance the search behavior of the Golden Eagle Optimizer. The Black Widow Optimizer provides strong intensification through procreation, cannibalism, and mutation mechanisms, whereas the Golden Eagle Optimizer provides a balanced search process through its cruise and attack strategies. Experimental results show that the Black Widow Optimizer achieved better individual performance than the Golden Eagle Optimizer, with average RPD values of 0.855% and 1.068%, respectively. However, the hybrid strategy based on incorporating the mutation mechanism into the Golden Eagle Optimizer produced the best result, reaching an RPD of 0.592%. The study also employed the Wilcoxon–Mann–Whitney statistical test to validate the performance differences among algorithms, and the respective Big-O computational complexity was calculated. These findings highlight the potential of hybrid metaheuristics for designing robust and efficient manufacturing systems.
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(This article belongs to the Special Issue Advanced Nature-Inspired Optimization Algorithms)
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