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Proceedings 2017, 1(4), 605; doi:10.3390/proceedings1040605

Submucosal Exploration of EMG and Physiological Parameters in the Bladder Wall

1
KU Leuven, ESAT-MICAS, Leuven, Belgium
2
KU Leuven, Unit of Organ Systems, Leuven, Belgium
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 18 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [1572 KB, uploaded 13 October 2017]

Abstract

An implantable sensor system has been developed to explore the physiological behaviour of the bladder wall. It consists of a 3-axis digital accelerometer and a pressure sensor on the upper side of a flexible polyimide printed circuit board. On the bottom side, two metallic hooks prevent migration of the device in the bladder wall while simultaneously acting as electrodes to record the electrical activity of the detrusor muscle. The full system is inserted at the interface between the detrusor and the mucosa, preventing exposure of the transducer to the urine. This ensures protection both for inflammation of the inner bladder, and from salts deposition on the device. Three packaging layers have been applied to ensure biocompatibility of the device: Parylene-C, medical epoxy and PDMS. The device was first tested in-vitro for water diffusion. Then, the feasibility of submucosal implant was demonstrated in a cadaver pig bladder, and in-vivo recordings were successfully acquired in a rat.
Keywords: bladder wall; submucosal; acceleration; pressure; biocompatible packaging. bladder wall; submucosal; acceleration; pressure; biocompatible packaging.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Brancato, L.; Weydts, T.; Soebadi, M.A.; Ridder, D.D.; Puers, R. Submucosal Exploration of EMG and Physiological Parameters in the Bladder Wall. Proceedings 2017, 1, 605.

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