Next Article in Journal
Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology
Previous Article in Journal
A Non Invasive Sensor System for the Screening of Obstructive Sleep Apnea Syndrome
Article Menu
Issue 4 (September) cover image

Article Versions

Export Article

Open AccessProceedings
Proceedings 2017, 1(4), 541; doi:10.3390/proceedings1040541

Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles

1
Center for Integrated Sensor Systems, Danube University Krems, 2700 Wr. Neustadt, Austria
2
PROFACTOR GmbH, 4407 Steyr-Gleink, Austria
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 7 August 2017
Download PDF [1308 KB, uploaded 4 September 2017]

Abstract

We report on a nanoparticle-based biosensor that represents a label-free homogeneous bioassay suitable for in-vitro biomolecular diagnostics. The underlying detection principle is based on the optical observation of the rotational dynamics of multicomponent nanoparticles utilizing magnetic and plasmonic properties. The plasmon-optical properties of the anisotropic nanoparticles depending on their material composition and geometrical design were investigated by numerical simulations. Based on such an analysis, monodisperse magneto-plasmonic nanoparticles were fabricated using physical fabrication methods. Rotational dynamics measurements revealed the lowest detectable particle concentration in the picomolar (ng/mL) regime, which is very promising in reaching the biomolecular limit of detection which is relevant for routine clinical diagnostics.
Keywords: Magnetic-Lab-on-a-Bead; biosensor; nanoparticle; magnetic; plasmonic; point-of-care diagnostics; nanoimprint lithography; homogeneous immunoassay Magnetic-Lab-on-a-Bead; biosensor; nanoparticle; magnetic; plasmonic; point-of-care diagnostics; nanoimprint lithography; homogeneous immunoassay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shoshi, A.; Schneeweiss, P.; Haslinger, M.J.; Glatzl, T.; Kovács, G.; Schinerl, J.; Muehlberger, M.; Brueckl, H. Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles. Proceedings 2017, 1, 541.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top