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Proceedings 2017, 1(4), 506; doi:10.3390/proceedings1040506

Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology

1
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
2
Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6-10, 35037 Marburg, Germany
3
Division of Endocrinology and Metabolism, Rostock University Medical Center, Ernst-Heydemann-Street 6, 18057 Rostock, Germany
4
Peter Grünberg Institute (PGI-8, Bioelectronics), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Street 6, 52425 Jülich, Germany
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 7 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [385 KB, uploaded 11 October 2017]

Abstract

An amperometric biosensor based on the bioelectrocatalytic measurement principle for the detection of adrenaline has been developed. The adrenaline sensor has been prepared by modification of a platinum thin-film electrode with a pyrroloquinoline quinone-dependent glucose dehydrogenase. The enzyme was immobilized via cross-linking method. Lower detection limit of 1 nM of adrenaline has been achieved by measuring at physiological level at pH 7.4.
Keywords: chip-based biosensor; adrenaline; glucose dehydrogenase; bioelectrocatalysis chip-based biosensor; adrenaline; glucose dehydrogenase; bioelectrocatalysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Molinnus, D.; Hardt, G.; Käver, L.; Willenberg, H.S.; Poghossian, A.; Keusgen, M.; Schöning, M.J. Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology. Proceedings 2017, 1, 506.

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