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Fermentation 2016, 2(1), 4; doi:10.3390/fermentation2010004

Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions

Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: George N. Bennett
Received: 20 December 2015 / Revised: 4 February 2016 / Accepted: 14 February 2016 / Published: 19 February 2016
(This article belongs to the Special Issue Metabolic Engineering)
View Full-Text   |   Download PDF [746 KB, uploaded 19 February 2016]   |  


Production of small molecule drugs in a recombinant host is becoming an increasingly popular alternative to chemical synthesis or production in natural hosts such as plants due to the ease of growing microorganisms with higher titers and less cost. While there are a wide variety of well-developed cloning techniques to produce small molecule drugs in a heterologous host, there are still many challenges towards efficient production. Therefore, this paper reviews some of these recently developed tools for metabolic engineering and categorizes them according to a chronological series of steps for a generalized method of drug production in a heterologous host, including 1) pathway discovery from a natural host, 2) pathway assembly in the recombinant host, and 3) pathway optimization to increase titers and yield. View Full-Text
Keywords: metabolic engineering; pathway discovery; pathway assembly; pathway optimization metabolic engineering; pathway discovery; pathway assembly; pathway optimization

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Huttanus, H.M.; Sheng, J.; Feng, X. Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions. Fermentation 2016, 2, 4.

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