Next Article in Journal
Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain
Previous Article in Journal
Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Non-Coding RNA 2018, 4(2), 14; https://doi.org/10.3390/ncrna4020014

Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition

Cardiovascular Development Group, Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain
*
Author to whom correspondence should be addressed.
Received: 28 March 2018 / Revised: 22 May 2018 / Accepted: 23 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Non-Coding RNA and Cell Migration)
Full-Text   |   PDF [1230 KB, uploaded 28 May 2018]   |  

Abstract

Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading to filopodia formation and the progressive up-regulation of a mesenchymal gene expression pattern enabling cell migration. Epithelial-to-mesenchymal transition is already observed in early embryonic stages such as gastrulation, when the epiblast undergoes an EMT process and therefore leads to the formation of the third embryonic layer, the mesoderm. Epithelial-to-mesenchymal transition is pivotal in multiple embryonic processes, such as for example during cardiovascular system development, as valve primordia are formed and the cardiac jelly is progressively invaded by endocardium-derived mesenchyme or as the external cardiac cell layer is established, i.e., the epicardium and cells detached migrate into the embryonic myocardial to form the cardiac fibrous skeleton and the coronary vasculature. Strikingly, the most important biological event in which EMT is pivotal is cancer development and metastasis. Over the last years, understanding of the transcriptional regulatory networks involved in EMT has greatly advanced. Several transcriptional factors such as Snail, Slug, Twist, Zeb1 and Zeb2 have been reported to play fundamental roles in EMT, leading in most cases to transcriptional repression of cell–cell interacting proteins such as ZO-1 and cadherins and activation of cytoskeletal markers such as vimentin. In recent years, a fundamental role for non-coding RNAs, particularly microRNAs and more recently long non-coding RNAs, has been identified in normal tissue development and homeostasis as well as in several oncogenic processes. In this study, we will provide a state-of-the-art review of the functional roles of non-coding RNAs, particularly microRNAs, in epithelial-to-mesenchymal transition in both developmental and pathological EMT. View Full-Text
Keywords: epithelial-to-mesenchymal transition; microRNA; lncRNAs; transcriptional regulation; post-transcriptional regulation epithelial-to-mesenchymal transition; microRNA; lncRNAs; transcriptional regulation; post-transcriptional regulation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Expósito-Villén, A.; E. Aránega, A.; Franco, D. Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition. Non-Coding RNA 2018, 4, 14.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Non-Coding RNA EISSN 2311-553X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top