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Non-Coding RNA 2016, 2(4), 14; doi:10.3390/ncrna2040014

Current perspectives in Set7 mediated stem cell differentiation

1
Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
2
Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
3
Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3004, Australia
4
Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia
5
Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR
*
Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Received: 26 October 2016 / Revised: 18 November 2016 / Accepted: 23 November 2016 / Published: 4 December 2016
(This article belongs to the Special Issue The Biology of Non-Coding RNAs and Metabolic Diseases)
View Full-Text   |   Download PDF [624 KB, uploaded 8 December 2016]   |  

Abstract

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity. View Full-Text
Keywords: Set7; stem cell differentiation; non-coding RNA; histone; non-histone protein Set7; stem cell differentiation; non-coding RNA; histone; non-histone protein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Karimnia, N.; Rafehi, H.; Tuano, N.K.; Ziemann, M.; K.N, H.; Okabe, J.; El-Osta, A. Current perspectives in Set7 mediated stem cell differentiation. Non-Coding RNA 2016, 2, 14.

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