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Open AccessCommunication
Non-Coding RNA 2016, 2(2), 3; doi:10.3390/ncrna2020003

Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway

Infection and Immunity, St. George’s University of London, Cranmer Terrace, London SW17 0RE, UK
Academic Editor: George A. Calin
Received: 7 March 2016 / Revised: 22 April 2016 / Accepted: 9 May 2016 / Published: 20 May 2016
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Abstract

Nuclear factor of activated T cells (NFAT) is a family of transcription factors important for innate and adaptive immune responses. NFAT activation is tightly regulated through the calcineurin/NFAT signaling pathway. There is increasing evidence on non-coding RNAs such as miRNAs playing a crucial role in regulating transcription factors and signaling pathways. However, not much is known about microRNAs (miRNAs) targeting the calcineurin/NFAT signaling pathway involved in immune response in human. In this study, a comprehensive pathway level analysis has been carried out to identify miRNAs regulating the calcineurin/NFAT signaling pathway. Firstly, by incorporating experimental data and computational predictions, 191 unique miRNAs were identified to be targeting the calcineurin/NFAT signaling pathway in humans. Secondly, combining miRNA expression data from activated T cells and computational predictions, 32 miRNAs were observed to be induced by NFAT transcription factors. Finally, 11 miRNAs were identified to be involved in a feedback loop to modulate the calcineurin/NFAT signaling pathway activity. This data demonstrate the potential role of miRNAs as regulators of the calcineurin/NFAT signaling pathway. The present study thus emphasizes the importance of pathway level analysis to identify miRNAs and understands their role in modulating signaling pathways and transcription factor activity. View Full-Text
Keywords: miRNA targets; calcineurin/NFAT signaling pathway; pathway regulation; feedback loops miRNA targets; calcineurin/NFAT signaling pathway; pathway regulation; feedback loops
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kannambath, S. Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway. Non-Coding RNA 2016, 2, 3.

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