Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway
AbstractNuclear factor of activated T cells (NFAT) is a family of transcription factors important for innate and adaptive immune responses. NFAT activation is tightly regulated through the calcineurin/NFAT signaling pathway. There is increasing evidence on non-coding RNAs such as miRNAs playing a crucial role in regulating transcription factors and signaling pathways. However, not much is known about microRNAs (miRNAs) targeting the calcineurin/NFAT signaling pathway involved in immune response in human. In this study, a comprehensive pathway level analysis has been carried out to identify miRNAs regulating the calcineurin/NFAT signaling pathway. Firstly, by incorporating experimental data and computational predictions, 191 unique miRNAs were identified to be targeting the calcineurin/NFAT signaling pathway in humans. Secondly, combining miRNA expression data from activated T cells and computational predictions, 32 miRNAs were observed to be induced by NFAT transcription factors. Finally, 11 miRNAs were identified to be involved in a feedback loop to modulate the calcineurin/NFAT signaling pathway activity. This data demonstrate the potential role of miRNAs as regulators of the calcineurin/NFAT signaling pathway. The present study thus emphasizes the importance of pathway level analysis to identify miRNAs and understands their role in modulating signaling pathways and transcription factor activity. View Full-Text
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Kannambath, S. Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway. Non-Coding RNA 2016, 2, 3.
Kannambath S. Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway. Non-Coding RNA. 2016; 2(2):3.Chicago/Turabian Style
Kannambath, Shichina. 2016. "Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway." Non-Coding RNA 2, no. 2: 3.
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