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J. Fungi 2018, 4(2), 51; https://doi.org/10.3390/jof4020051

Burden of Serious Fungal Infections in Argentina

1
Infectology Department, Sanatorio Allende Córdoba, Av Hipólito Yirgoyen 384, Córdoba, Argentina
2
Infectious Diseases Section, Hospital Privado Universitario de Córdoba, Av. Naciones Unidas 346, Córdoba, Argentina
3
The Natonal Aspergillosis Centre, Wythenshawe Hospital, Manchester Academic Health Science Centre, and The University of Manchester, Manchester M23 9LT, UK
*
Authors to whom correspondence should be addressed.
Received: 14 February 2018 / Revised: 9 April 2018 / Accepted: 13 April 2018 / Published: 24 April 2018
(This article belongs to the Special Issue Fungal Burden in Different Countries)
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Abstract

The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Some additional data were sourced from the Ministry of Health, the Global Initiative for Asthma (GINA) program, and national haematology and transplant societies. Argentina has a population of 43.8 million, with 25% of this total being children under 15 years. The predicted candidemia annual incidence is 2193 cases, with 50% occurring in the ICU. At a 6% prevalence rate, an estimated 593,695 women suffer from recurrent vulvovaginal candidiasis. Invasive aspergillosis is relatively common because of high smoking and chronic obstructive pulmonary disease (COPD) rates, with 268 cases in immunocompromised patients and another 1938 in the 168,000 COPD patients admitted to hospital. Asthma is also common, affecting 14% of adults, and so allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS) are major problems. An estimated 432 cases of cryptococcal meningitis (CM)—90% of them in AIDS patients—and 1177 cases of Pneumocystis pneumonia (PCP) occur each year. The estimated annual case number of disseminated histoplasmosis is 404 in AIDS patients, almost as frequent as CM. Paracoccidioidomycosis annual incidence is estimated at 219, and coccidioidomycosis at 16 cases. At least 881,023 people (>2.01%) in Argentina are affected by a serious fungal disease annually, with considerable morbidity and mortality. View Full-Text
Keywords: mycoses; epidemiology; aspergillosis; candidemia; fungal infections mycoses; epidemiology; aspergillosis; candidemia; fungal infections
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Riera, F.O.; Caeiro, J.P.; Denning, D.W. Burden of Serious Fungal Infections in Argentina. J. Fungi 2018, 4, 51.

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