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J. Fungi 2018, 4(2), 50; https://doi.org/10.3390/jof4020050

Lipid Biosynthesis as an Antifungal Target

1,2,* , 1
and
3,*
1
Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
2
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin 300071, China
3
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA
*
Authors to whom correspondence should be addressed.
Received: 23 March 2018 / Revised: 17 April 2018 / Accepted: 18 April 2018 / Published: 20 April 2018
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Abstract

Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles in the regulation of cell metabolism by acting as signaling molecules. Neutral lipids, including TAGs and sterol esters (STEs), are important storage lipids in cells. In view of the importance of lipid molecules, this review briefly summarizes the metabolic pathways for sterols, phospholipids, sphingolipids, fatty acids, and neutral lipids in fungi and illustrates the differences between fungal and human (or other mammalian) cells, especially in relation to lipid biosynthetic pathways. These differences might provide valuable clues for us to find target proteins for novel antifungal drugs. In addition, the development of lipidomics technology in recent years has supplied us with a shortcut for finding new antifungal drug targets; this ability is important for guiding our research on pathogenic fungi. View Full-Text
Keywords: lipid metabolism; pathogenic fungi; antifungal drugs; target protein; lipidomics lipid metabolism; pathogenic fungi; antifungal drugs; target protein; lipidomics
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Pan, J.; Hu, C.; Yu, J.-H. Lipid Biosynthesis as an Antifungal Target. J. Fungi 2018, 4, 50.

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