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J. Fungi 2017, 3(4), 51; doi:10.3390/jof3040051

Fungal Strategies to Evade the Host Immune Recognition

1
Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P., Guanajuato Gto. 36050, México
2
Unidad Académica Multidisciplinaria Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, C.P., Cd. Valle SLP. 79060, México
*
Author to whom correspondence should be addressed.
Received: 15 August 2017 / Revised: 18 September 2017 / Accepted: 19 September 2017 / Published: 23 September 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
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Abstract

The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells. Here, we performed a thorough revision of the main fungal tactics to escape from the host immunosurveillance processes. These include the composition and organization of the cell wall, the fungal capsule, the formation of titan cells, biofilms, and asteroid bodies; the ability to undergo dimorphism; and the escape from nutritional immunity, extracellular traps, phagocytosis, and the action of humoral immune effectors. View Full-Text
Keywords: fungal pathogen; cell wall; immune system; dimorphism; Aspergillus; Cryptococcus; Candida; Sporothrix; Paracoccidioides; phagocytosis fungal pathogen; cell wall; immune system; dimorphism; Aspergillus; Cryptococcus; Candida; Sporothrix; Paracoccidioides; phagocytosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hernández-Chávez, M.J.; Pérez-García, L.A.; Niño-Vega, G.A.; Mora-Montes, H.M. Fungal Strategies to Evade the Host Immune Recognition. J. Fungi 2017, 3, 51.

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