The Role of IL-17 in Protection against Mucosal Candida Infections
AbstractInterleukin-17 (IL-17) is a proinflammatory cytokine produced by adaptive CD4+ T helper cells and innate lymphocytes, such as γδ-T cells and TCRβ+ “natural” Th17 cells. IL-17 activates signaling through the IL-17 receptor, which induces other proinflammatory cytokines, antimicrobial peptides and neutrophil chemokines that are important for antifungal activity. The importance of IL-17 in protective antifungal immunity is evident in mice and humans, where various genetic defects related to the IL-17-signaling pathway render them highly susceptible to forms of candidiasis such oropharyngeal candidiasis (OPC) or more broadly chronic mucocutaneous candidiasis (CMC), both caused mainly by the opportunistic fungal pathogen Candida albicans. OPC is common in infants and the elderly, HIV/AIDS and patients receiving chemotherapy and/or radiotherapy for head and neck cancers. This review focuses on the role of IL-17 in protection against candidiasis, and includes a brief discussion of non-Candida albicans fungal infections, as well as how therapeutic interventions blocking IL-17-related components can affect antifungal immunity. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Mengesha, B.G.; Conti, H.R. The Role of IL-17 in Protection against Mucosal Candida Infections. J. Fungi 2017, 3, 52.
Mengesha BG, Conti HR. The Role of IL-17 in Protection against Mucosal Candida Infections. Journal of Fungi. 2017; 3(4):52.Chicago/Turabian Style
Mengesha, Bemnet G.; Conti, Heather R. 2017. "The Role of IL-17 in Protection against Mucosal Candida Infections." J. Fungi 3, no. 4: 52.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.