Next Article in Journal
Local-Level Genetic Diversity and Structure of Matsutake Mushroom (Tricholoma matsutake) Populations in Nagano Prefecture, Japan, Revealed by 15 Microsatellite Markers
Next Article in Special Issue
Metabolic Interactions between Bacteria and Fungi in Commensal Oral Biofilms
Previous Article in Journal
Quantitative Assessment of Grapevine Wood Colonization by the Dieback Fungus Eutypa lata
Previous Article in Special Issue
Activity of Amphotericin B and Anidulafungin Combined with Rifampicin, Clarithromycin, Ethylenediaminetetraacetic Acid, N-Acetylcysteine, and Farnesol against Candida tropicalis Biofilms
Article Menu

Export Article

Open AccessReview
J. Fungi 2017, 3(2), 22; doi:10.3390/jof3020022

Fungal Biofilms and Polymicrobial Diseases

1
Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara SP 14800-903, Brazil
2
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba SP 13414-018, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Mahmoud A. Ghannoum
Received: 22 February 2017 / Revised: 19 April 2017 / Accepted: 4 May 2017 / Published: 10 May 2017
(This article belongs to the Special Issue Fungal Biofilms)
View Full-Text   |   Download PDF [1569 KB, uploaded 10 May 2017]   |  

Abstract

Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized communities that are resistant to antimicrobials and environmental conditions. In recent years, new genera of fungi have been correlated with biofilm formation. However, Candida biofilms remain the most widely studied from the morphological and molecular perspectives. Biofilms formed by yeast and filamentous fungi present differences, and studies of polymicrobial communities have become increasingly important. A key feature of resistance is the extracellular matrix, which covers and protects biofilm cells from the surrounding environment. Furthermore, to achieve cell–cell communication, microorganisms secrete quorum-sensing molecules that control their biological activities and behaviors and play a role in fungal resistance and pathogenicity. Several in vitro techniques have been developed to study fungal biofilms, from colorimetric methods to omics approaches that aim to identify new therapeutic strategies by developing new compounds to combat these microbial communities as well as new diagnostic tools to identify these complex formations in vivo. In this review, recent advances related to pathogenic fungal biofilms are addressed. View Full-Text
Keywords: fungal biofilms; polymicrobial biofilms; resistance; omics approaches; drug discovery; drug combination; in vitro techniques; in vivo techniques fungal biofilms; polymicrobial biofilms; resistance; omics approaches; drug discovery; drug combination; in vitro techniques; in vivo techniques
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Costa-Orlandi, C.B.; Sardi, J.C.O.; Pitangui, N.S.; de Oliveira, H.C.; Scorzoni, L.; Galeane, M.C.; Medina-Alarcón, K.P.; Melo, W.C.M.A.; Marcelino, M.Y.; Braz, J.D.; Fusco-Almeida, A.M.; Mendes-Giannini, M.J.S. Fungal Biofilms and Polymicrobial Diseases. J. Fungi 2017, 3, 22.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top