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J. Fungi 2017, 3(2), 19; doi:10.3390/jof3020019

Antifungal Susceptibility Testing of Fusarium: A Practical Approach

1
Westerdijk Fungal Biodiversity Institute, PO Box 85167, 3508 AD Utrecht, The Netherlands
2
Centre of Expertise in Mycology Radboud University Medical Centre, Canisius Wilhelmina Hospital, 6500HB Nijmegen, The Netherlands
3
Ministry of Health, Directorate General of Health Services, PO Box 393, 100 Muscat, Oman
4
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, 6500HB Nijmegen, The Netherlands
5
Basic Pathology Department, Federal University of Paraná State, Curitiba, 81540-970 Paraná, Brazil
6
Biological Sciences Department, Faculty of Science, King Abdulaziz University, PO Box 80203 Jeddah, Saudi Arabia
7
Department of Medical Microbiology, Radboud University, Nijmegen Medical Centre, 6500GS Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Ana Alastruey-Izquierdo and Stéphane Ranque
Received: 12 March 2017 / Revised: 14 April 2017 / Accepted: 19 April 2017 / Published: 26 April 2017
(This article belongs to the Special Issue Antifungal Susceptibility Testing)
View Full-Text   |   Download PDF [2087 KB, uploaded 26 April 2017]   |  

Abstract

In vitro susceptibility testing of Fusarium is becoming increasingly important because of frequency and diversity of infections and because resistance profiles are species-specific. Reference methods for antifungal susceptibility testing (AFST) are those of Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility (EUCAST), but breakpoints (BPs) have not yet been established. One of the problems is that phylogenetic distances between Fusarium species are much smaller than between species of, e.g., Candida. Epidemiological cutoff values (ECVs) for some Fusarium species have been determined in order to differentiate wild-type from non-wild-type isolates. In clinical routine, commercially available assays such as Etest, Sensititre or others provide essential agreement with reference methods. Our objective is to summarize antifungal susceptibility testing of Fusarium genus in the clinical laboratory: how to do it, when to do it, and how to interpret it. View Full-Text
Keywords: Fusarium; susceptibility test; clinical laboratory; CLSI; EUCAST; Etest Fusarium; susceptibility test; clinical laboratory; CLSI; EUCAST; Etest
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MDPI and ACS Style

Al-Hatmi, A.M.S.; Curfs-Breuker, I.; de Hoog, G.S.; Meis, J.F.; Verweij, P.E. Antifungal Susceptibility Testing of Fusarium: A Practical Approach. J. Fungi 2017, 3, 19.

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