Next Article in Journal / Special Issue
The Popeye Domain Containing Genes and Their Function as cAMP Effector Proteins in Striated Muscle
Previous Article in Journal
Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
Previous Article in Special Issue
Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System
Article Menu

Export Article

Open AccessFeature PaperReview
J. Cardiovasc. Dev. Dis. 2018, 5(1), 17; https://doi.org/10.3390/jcdd5010017

Using cAMP Sensors to Study Cardiac Nanodomains

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, South Parks Road, Oxford OX1 3PT, UK
*
Author to whom correspondence should be addressed.
Received: 20 February 2018 / Revised: 9 March 2018 / Accepted: 9 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
View Full-Text   |   Download PDF [1379 KB, uploaded 13 March 2018]   |  

Abstract

3′,5′-cyclic adenosine monophosphate (cAMP) signalling plays a major role in the cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters. In recent years, evidence has accumulated demonstrating that the cAMP response to different extracellular agonists is not uniform: depending on the stimulus, cAMP signals of different amplitudes and kinetics are generated in different subcellular compartments, eliciting defined physiological effects. In this review, we focus on how real-time imaging using fluorescence resonance energy transfer (FRET)-based reporters has provided mechanistic insight into the compartmentalisation of the cAMP signalling pathway and allowed for the precise definition of the regulation and function of subcellular cAMP nanodomains. View Full-Text
Keywords: 3′,5′-cyclic adenosine monophosphate; protein kinase A; fluorescence resonance energy transfer; real-time imaging; compartmentalisation; signalling; cardiac biology; phosphodiesterases; A kinase anchoring proteins 3′,5′-cyclic adenosine monophosphate; protein kinase A; fluorescence resonance energy transfer; real-time imaging; compartmentalisation; signalling; cardiac biology; phosphodiesterases; A kinase anchoring proteins
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Schleicher, K.; Zaccolo, M. Using cAMP Sensors to Study Cardiac Nanodomains. J. Cardiovasc. Dev. Dis. 2018, 5, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top