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J. Cardiovasc. Dev. Dis. 2018, 5(1), 15; https://doi.org/10.3390/jcdd5010015

Oxidative DNA Damage and Carotid Intima Media Thickness as Predictors of Cardiovascular Disease in Prediabetic Subjects

1
Department of Biochemistry, Gajra Raja Medical College, Gwalior 474009, India
2
Department of Radiodiagnosis, Gajra Raja Medical College, Gwalior 474009, India
*
Author to whom correspondence should be addressed.
Received: 7 February 2018 / Revised: 24 February 2018 / Accepted: 5 March 2018 / Published: 7 March 2018
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Abstract

Prediabetes is considered as a risk factor for the development of diabetes mellitus and cardiovascular disease. The present study was conducted with the aim of finding out the relationship between oxidative DNA damage and carotid intima media thickness for the prediction of cardiovascular disease in prediabetic subjects. The study included 100 prediabetic subjects and 100 normal individuals as controls. In both cases and controls, 8-OHdG was measured by ELISA, and CIMT was measured by B mode ultrasonography. Both 8-OHdG and CIMT were significantly higher in subjects with prediabetes as compared to controls (185.80 ± 10.72 pg/mL vs. 126.13 ± 16.01 pg/mL, p < 0.001 and 0.70 ± 0.04 mm vs. 0.57 ± 0.03 mm, p < 0.001, respectively). There was significant and positive correlation of IGT with 8-OHdG (r = 0.783; p < 0.001) and CIMT (r = 0.787; p < 0.001) in prediabetic subjects. Moreover, 8-OHdG showed significant positive correlation with CIMT (r = 0.704; p < 0.001) in prediabetic subjects. In conclusion, increased 8-OHdG and CIMT in prediabetic subjects indicate that biochemical changes of atherosclerosis start even before the onset of diabetes mellitus. Hence, 8-OHdG and CIMT could be used as indicators of cardiovascular disease risk in these subjects. View Full-Text
Keywords: prediabetes; 8-hydroxy-2-deoxy-guanosine; carotid intima media thickness; cardiovascular disease prediabetes; 8-hydroxy-2-deoxy-guanosine; carotid intima media thickness; cardiovascular disease
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Mahat, R.K.; Singh, N.; Gupta, A.; Rathore, V. Oxidative DNA Damage and Carotid Intima Media Thickness as Predictors of Cardiovascular Disease in Prediabetic Subjects. J. Cardiovasc. Dev. Dis. 2018, 5, 15.

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