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J. Cardiovasc. Dev. Dis. 2017, 4(2), 5; doi:10.3390/jcdd4020005

Lineages of the Cardiac Conduction System

Department of Medical Biology, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands
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Author to whom correspondence should be addressed.
Academic Editor: Robert E. Poelmann
Received: 22 March 2017 / Revised: 19 April 2017 / Accepted: 24 April 2017 / Published: 2 May 2017
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Abstract

The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties. A better understanding of the origin and specification of CCS lineages has allowed us to better comprehend the etiology of CCS disease and has provided leads for development of therapies. A variety of technologies and approaches have been used to investigate CCS lineages, which will be summarized in this review. The findings imply that there is not a single CCS lineage. In contrast, early cell fate decisions segregate the lineages of the CCS components while they remain connected to each other. View Full-Text
Keywords: cell lineage; lineage tracing; cardiac conduction system; cardiac conduction system lineage; genetic fate map; genetic inducible fate map; cardiac development cell lineage; lineage tracing; cardiac conduction system; cardiac conduction system lineage; genetic fate map; genetic inducible fate map; cardiac development
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Mohan, R.; Boukens, B.J.; Christoffels, V.M. Lineages of the Cardiac Conduction System. J. Cardiovasc. Dev. Dis. 2017, 4, 5.

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