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J. Cardiovasc. Dev. Dis. 2016, 3(3), 25; doi:10.3390/jcdd3030025

Ciona as a Simple Chordate Model for Heart Development and Regeneration

1
Department of Biology, Winthrop University, Rock Hill, SC 29732, USA
2
Department of Biology, New York University, New York, NY 10003, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Rolf Bodmer and Georg Vogler
Received: 23 April 2016 / Revised: 15 June 2016 / Accepted: 25 July 2016 / Published: 9 August 2016
(This article belongs to the Special Issue Non-mammalian Animal Models to Study Heart Development and Disease)
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Abstract

Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a basal Chordate, the Ciona model system presents a simple scaffold that recapitulates the basic blueprint of cardiac development in Chordates. Here we will focus on the development and cellular structure of the heart of the ascidian Ciona as compared to other Chordates, principally vertebrates. Comparison of the Ciona model system to heart development in other Chordates presents great potential for dissecting the genetic mechanisms that underlie congenital heart defects and disease at the cellular level and might provide additional insight into potential pathways for therapeutic cardiac regeneration. View Full-Text
Keywords: Ciona; cardiac development; cardiac cell specification; cardiac regeneration Ciona; cardiac development; cardiac cell specification; cardiac regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Evans Anderson, H.; Christiaen, L. Ciona as a Simple Chordate Model for Heart Development and Regeneration. J. Cardiovasc. Dev. Dis. 2016, 3, 25.

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