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J. Cardiovasc. Dev. Dis. 2016, 3(2), 14; doi:10.3390/jcdd3020014

Transcriptional Regulation of Heart Development in Zebrafish

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
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Author to whom correspondence should be addressed.
Academic Editors: Rolf Bodmer and Georg Vogler
Received: 13 February 2016 / Revised: 2 April 2016 / Accepted: 7 April 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Non-mammalian Animal Models to Study Heart Development and Disease)
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Abstract

Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human congenital heart diseases. Recent studies have expanded our understanding of the regulation of cardiac gene expression at an additional layer, involving the coordination of epigenetic and transcriptional regulators. In this review, we highlight and discuss discoveries made possible by the genetic and embryological tools available in the zebrafish model organism, with a focus on the novel functions of cardiac transcription factors and epigenetic and transcriptional regulatory proteins during cardiogenesis. View Full-Text
Keywords: zebrafish; heart development; transcription factors; epigenetic regulators zebrafish; heart development; transcription factors; epigenetic regulators
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Lu, F.; Langenbacher, A.D.; Chen, J.-N. Transcriptional Regulation of Heart Development in Zebrafish. J. Cardiovasc. Dev. Dis. 2016, 3, 14.

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