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J. Cardiovasc. Dev. Dis. 2016, 3(1), 7; doi:10.3390/jcdd3010007

Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly

GReD (Genetics, Reproduction and Development laboratory), INSERM U1103, CNRS UMR6293, University of Clermont-Ferrand, 28 place Henri-Dunant, 63000 Clermont-Ferrand, France
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Georg Vogler and Rolf Bodmer
Received: 31 December 2015 / Revised: 23 January 2016 / Accepted: 6 February 2016 / Published: 18 February 2016
(This article belongs to the Special Issue Non-mammalian Animal Models to Study Heart Development and Disease)
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Abstract

Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional heart phenotypes. Identification of molecular and functional mechanisms disrupted by mutations causing channelopathies and cardiomyopathies is essential to understanding the link between an altered gene and clinical phenotype. The development of animal models has been proven to be efficient for functional studies in channelopathies and cardiomyopathies. In particular, the Drosophila model has been largely applied for deciphering the molecular and cellular pathways affected in these inherited cardiac disorders and for identifying their genetic modifiers. Here we review the utility and the main contributions of the fruitfly models for the better understanding of channelopathies and cardiomyopathies. We also discuss the investigated pathological mechanisms and the discoveries of evolutionarily conserved pathways which reinforce the value of Drosophila in modeling human cardiac diseases. View Full-Text
Keywords: human cardiac disease; Drosophila; channelopathies; cardiomyopathies; sarcomeric proteins; cytoskeletal proteins; K+ channels human cardiac disease; Drosophila; channelopathies; cardiomyopathies; sarcomeric proteins; cytoskeletal proteins; K+ channels
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Taghli-Lamallem, O.; Plantié, E.; Jagla, K. Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly. J. Cardiovasc. Dev. Dis. 2016, 3, 7.

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J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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