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J. Cardiovasc. Dev. Dis. 2014, 1(1), 29-36; doi:10.3390/jcdd1010029

Molecular Control of Cardiac Fetal/Neonatal Remodeling

Division of Medicine, University College London, London WC1 E6JJ, UK
Received: 19 December 2013 / Revised: 19 March 2014 / Accepted: 21 March 2014 / Published: 26 March 2014
View Full-Text   |   Download PDF [318 KB, uploaded 26 March 2014]

Abstract

Immediately following birth, the mammalian heart switches from generating ATP via glycolysis to β-oxidation of lipid. Coincident with this metabolic remodeling, cardiomyocyte mitosis ceases and regenerative capacity is lost. Recently, our understanding of the molecular pathways linking physiological stimuli with gene expression and phenotype changes around birth has increased, although fundamental gaps remain. This review discusses recent work that sheds light on this important area of mammalian cardiovascular development.
Keywords: cardiac; neonatal; metabolism; HIF; PPAR cardiac; neonatal; metabolism; HIF; PPAR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Breckenridge, R.A. Molecular Control of Cardiac Fetal/Neonatal Remodeling. J. Cardiovasc. Dev. Dis. 2014, 1, 29-36.

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