J. Cardiovasc. Dev. Dis. 2014, 1(1), 14-28; doi:10.3390/jcdd1010014
Review

Evolution of the Sinus Venosus from Fish to Human

1,2,* email, 3email, 1email, 2email and 2email
Received: 1 February 2014; in revised form: 10 March 2014 / Accepted: 10 March 2014 / Published: 21 March 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The sinus venosus, the cardiac chamber upstream of the (right) atrium, is a severely underinvestigated structure. Yet, its myocardium harbors the cardiac pacemaker in all vertebrates. In human, ectopic pacemaking and subsequent pathologies may originate from sinus venosus-derived myocardium surrounding the coronary sinus and the superior caval vein. In ectothermic vertebrates, i.e., fishes, amphibians and reptiles, the sinus venosus aids atrial filling by contracting prior to the atrium (atria). This is facilitated by the sinuatrial delay of approximately the same duration as the atrioventricular delay, which facilitates atrial filling of the ventricles. In mammals, the sinuatrial delay is lost, and the sinus venosus-derived myocardium persists as an extensive myocardial sheet surrounding the caval veins, which is activated in synchrony with the myocardium of the atria. The caval vein myocardium is hardly of significance in the healthy formed heart, but we suggest that the sinus venosus functions as a chamber during development when cardiac output, heart rate, blood pressure and architecture is much more like that of ectothermic vertebrates. The remodeling of the sinus venosus in mammals may be an adaptation associated with the high heart rates necessary for postnatal endothermy. If so, the endothermic birds should exhibit a similar remodeling as mammals, which remains to be investigated.
Keywords: sinus venosus; heart; conduction system; evolution
PDF Full-text Download PDF Full-Text [591 KB, uploaded 21 March 2014 14:10 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Jensen, B.; Boukens, B.J.D.; Wang, T.; Moorman, A.F.M.; Christoffels, V.M. Evolution of the Sinus Venosus from Fish to Human. J. Cardiovasc. Dev. Dis. 2014, 1, 14-28.

AMA Style

Jensen B, Boukens BJD, Wang T, Moorman AFM, Christoffels VM. Evolution of the Sinus Venosus from Fish to Human. Journal of Cardiovascular Development and Disease. 2014; 1(1):14-28.

Chicago/Turabian Style

Jensen, Bjarke; Boukens, Bastiaan J.D.; Wang, Tobias; Moorman, Antoon F.M.; Christoffels, Vincent M. 2014. "Evolution of the Sinus Venosus from Fish to Human." J. Cardiovasc. Dev. Dis. 1, no. 1: 14-28.

J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert