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Geriatrics 2017, 2(3), 29; doi:10.3390/geriatrics2030029

Systematic Review of Cholinesterase Inhibitors on Cognition and Behavioral Symptoms in Patients of Chinese Descent with Alzheimer’s Disease, Vascular Dementia, or Mixed Dementia

1
LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China
2
Division of Neurology, Department of Medicine, Queen Mary Hospital, Hong Kong, China
3
Dean’s Office, Faculty of Medicine and Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
*
Author to whom correspondence should be addressed.
Received: 24 July 2017 / Revised: 24 August 2017 / Accepted: 25 August 2017 / Published: 27 August 2017
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Abstract

Cholinesterase inhibitors (ChEIs) are the primary pharmacologic treatment for dementia. Their efficacy in patients of Chinese descent is not well described. We reviewed how ChEIs could affect cognition and behavioral and psychological symptoms (BPSD) in Chinese patients with Alzheimer’s disease (AD), vascular dementia (VaD), or mixed (AD with vascular component) dementia. MEDLINE, PsycINFO, EMBASE and CINAHL were systematically searched for controlled trials of ChEIs, including donepezil, galantamine, and rivastigmine, for Chinese patients with AD, VaD, or mixed dementia. Outcomes for cognition and BPSD were extracted for discussion. Fifty-four studies were identified. While one larger study found that dementia patients of Chinese descent treated with ChEIs had significantly higher mean Mini-Mental State Examination (MMSE) score, other studies showed no significant difference. Evidence on BPSD after use of ChEIs was also conflicting. ChEIs may be effective in improving cognition among patients of Chinese descent with dementia. Further studies are needed to examine the possible effects of ChEIs on BPSD in Chinese patients with dementia in view of the small number of studies and limitations in their methodologies. View Full-Text
Keywords: Chinese; dementia; cholinesterase inhibitors; cognition; behavior Chinese; dementia; cholinesterase inhibitors; cognition; behavior
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MDPI and ACS Style

Leung, K.-C.; Li, V.; Ng, Y.-Z.; Chan, T.-T.; Chang, R.S.; Wong, R.Y. Systematic Review of Cholinesterase Inhibitors on Cognition and Behavioral Symptoms in Patients of Chinese Descent with Alzheimer’s Disease, Vascular Dementia, or Mixed Dementia. Geriatrics 2017, 2, 29.

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