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Vet. Sci. 2018, 5(2), 43; https://doi.org/10.3390/vetsci5020043

Effect of Propofol Continuous-Rate Infusion on Intravenous Glucose Tolerance Test in Dogs

1
Kitasato Laboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Higashi 23-35-1, Towada, Aomori 034-8628, Japan
2
Aso Animal Hospital, 5-12-5 Hikino, Fukuyama, Hirosima 721-0942, Japan
3
Togasaki animal hospital, 3-528-1 Togasaki, Misato, Saitama 341-0044, Japan
*
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 7 April 2018 / Accepted: 19 April 2018 / Published: 20 April 2018
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Abstract

Hyperglycemia causes perioperative complications and many anesthetics impair glucose metabolism and cause hyperglycemia. We evaluated the effects of propofol on blood glucose metabolism and insulin secretion during an intravenous glucose tolerance test (IVGTT) in dogs. Blood glucose, insulin, triglyceride, cholesterol, and free fatty acid (FFA) levels were measured in dogs during IVGTT in a conscious state and under the effect of 2.0% isoflurane, low-concentration propofol (0.2 mg/kg/min), and high-concentration propofol (0.4 mg/kg/min) anesthesia. Plasma glucose levels significantly increased in all of the treatment groups when compared with those in the conscious group. The prolonged half-life period of plasma glucose suggested that isoflurane and propofol attenuated glucose metabolism in dogs. Plasma insulin levels were significantly lower in the isoflurane group when compared with those in the other groups, whereas blood FFA levels were increased in the propofol groups when compared with the other groups. These results suggest that propofol itself does not directly raise plasma glucose levels, but attenuates glucose metabolism by accumulating FFA. View Full-Text
Keywords: anesthesia; propofol; glucose metabolism; dog; free fatty acid anesthesia; propofol; glucose metabolism; dog; free fatty acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Maeda, K.; Iwasaki, M.; Itou, Y.; Iwai, S.; Okano, S. Effect of Propofol Continuous-Rate Infusion on Intravenous Glucose Tolerance Test in Dogs. Vet. Sci. 2018, 5, 43.

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