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Vet. Sci. 2018, 5(1), 15;

Identification of Genetic Regions Associated with Scrotal Hernias in a Commercial Swine Herd

College of Veterinary Medicine, University of Passo Fundo, BR 285, São José, Passo Fundo, RS 99052-900, Brazil
Docentes do Programa de Pós-Graduação em Bioexperimentação-UPF, University of Passo Fundo, BR 285, São José, Passo Fundo, RS 99052-900, Brazil
Embrapa Suínos e Aves, Rodovia BR-153, Km110, Concórdia, SC 89715-899, Brazil
Embrapa Gado de Leite, Rua Eugênio do Nascimento, 610, Juiz de Fora, MG 36038-330, Brazil
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 24 January 2018 / Accepted: 25 January 2018 / Published: 27 January 2018
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In this paper, we have used two approaches to detect genetic associations with scrotal hernias in commercial pigs. Firstly, we have investigated the effects of runs of homozygosity (ROH) with the appearance of scrotal hernias, followed by a Genome Wide Association Study (GWAS). The phenotype classification was based on visual appearance of scrotal hernias. Each affected animal was matched to a healthy control from the same pen. In the total, 68 animals were genotyped using the Porcine SNP60 Beadchip, out of those, 41 animals had the presence of hernias and 27 were healthy animals. Fifteen animals were removed from the analysis due to differences in genetic background, leaving 18 healthy animals and 35 piglets with scrotal hernia. Further, the detection of extended haplotypes shared ROH were conducted for health (control) and affected (case) animals and a permutation test was used to test whether the ROH segments were more frequent in case/case pairs than non-case/case pairs. Using the ROH, we have identified an association (p = 0.019) on chromosome 2(SSC2) being segregated on animals with the presence of scrotal hernias. Using a GWAS, a region composed by 3 SNPs on the sexual chromosome X (SSCX) were associated with scrotal hernias (p < 1.6 × 10−5), this region harbors the Androgen Receptor Gene (AR). View Full-Text
Keywords: swine; genetics; hernias; SNP swine; genetics; hernias; SNP

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Lago, L.V.; Nery da Silva, A.; Zanella, E.L.; Groke Marques, M.; Peixoto, J.O.; da Silva, M.V.G.B.; Ledur, M.C.; Zanella, R. Identification of Genetic Regions Associated with Scrotal Hernias in a Commercial Swine Herd. Vet. Sci. 2018, 5, 15.

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