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Vet. Sci. 2017, 4(3), 34; doi:10.3390/vetsci4030034

Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human

1
Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, Scotland EH25 9RG, UK
2
Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, Scotland EH25 9RG, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Sonja Fonfara and Lynne O’Sullivan
Received: 1 March 2017 / Revised: 2 June 2017 / Accepted: 6 June 2017 / Published: 17 July 2017
(This article belongs to the Special Issue Comparison of Cardiovascular Systems and Diseases Across Species)
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Abstract

Myxomatous mitral valve disease is the single most important mitral valve disease in both dogs and humans. In the case of the dog it is ubiquitous, such that all aged dogs will have some evidence of the disease, and for humans it is known as Barlow’s disease and affects up to 3% of the population, with an expected increase in prevalence as the population ages. Disease in the two species show many similarities and while both have the classic myxomatous degeneration only in humans is there extensive fibrosis. This dual pathology of the human disease markedly affects the valve transcriptome and the difference between the dog and human is dominated by changes in genes associated with fibrosis. This review will briefly examine the comparative valve pathology and then, in more detail, the transcriptomic profiling and gene expression reported so far for both species. View Full-Text
Keywords: canine; human; myxomatous mitral valve disease; Barlow’s disease; transcriptomic profiling canine; human; myxomatous mitral valve disease; Barlow’s disease; transcriptomic profiling
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Markby, G.R.; Summers, K.M.; MacRae, V.E.; Corcoran, B.M. Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human. Vet. Sci. 2017, 4, 34.

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