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Vet. Sci. 2017, 4(1), 10; doi:10.3390/vetsci4010010

Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus)

1
College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville 4811, Queensland, Australia
2
School of Veterinary and Life Sciences, Murdoch University, South Street Campus, Murdoch 6150, Western Australia, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: David J. Argyle
Received: 13 October 2016 / Revised: 23 January 2017 / Accepted: 9 February 2017 / Published: 14 February 2017
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Abstract

Aside from a handful of notable exceptions, neoplasia is not reported as a major cause of mortality in wild animal populations and often goes undetected. For northern brown bandicoots specifically, there are few reported tumors in the literature and on file in the Australian Registry of Wildlife Health. This report describes a case of squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus), with metastases to the draining lymph nodes and lung. This neoplasm consisted predominantly of well-differentiated squamous cells and multifocal keratin pearls, with areas possibly consistent with epithelial to mesenchymal transition, as identified by positive immunohistochemical staining by both pancytokeratin (AE1/AE3) and vimentin. Additional investigations were negative for bandicoot papillomatosis carcinomatosis viruses. View Full-Text
Keywords: neoplasia; northern brown bandicoot; Isoodon macrourus; squamous cell carcinoma; immunohistochemistry; epithelial to mesenchymal transition neoplasia; northern brown bandicoot; Isoodon macrourus; squamous cell carcinoma; immunohistochemistry; epithelial to mesenchymal transition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Beck, A.P.; Shima, A.L.; Bennett, M.D.; Johnson, L.K. Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus). Vet. Sci. 2017, 4, 10.

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