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Bioengineering 2017, 4(2), 46; doi:10.3390/bioengineering4020046

Microtechnology-Based Multi-Organ Models

1
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea
2
Department of Chemical Engineering, Hongik University, Seoul 121-791, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Received: 19 March 2017 / Revised: 17 May 2017 / Accepted: 18 May 2017 / Published: 21 May 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
View Full-Text   |   Download PDF [2340 KB, uploaded 21 May 2017]   |  

Abstract

Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems have been developed and used to realize the ADME processes. However, conventional model systems have failed to simulate the ADME processes because they are different from in vivo, which has resulted in a high attrition rate of drugs and a decrease in the productivity of new drug development. Recently, a microtechnology-based in vitro system called “organ-on-a-chip” has been gaining attention, with more realistic cell behavior and physiological reactions, capable of better simulating the in vivo environment. Furthermore, multi-organ-on-a-chip models that can provide information on the interaction between the organs have been developed. The ultimate goal is the development of a “body-on-a-chip”, which can act as a whole body model. In this review, we introduce and summarize the current progress in the development of multi-organ models as a foundation for the development of body-on-a-chip. View Full-Text
Keywords: microtechnology; in vitro models; multi-organ chip; multiple organ interaction; microfluidics microtechnology; in vitro models; multi-organ chip; multiple organ interaction; microfluidics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, S.H.; Sung, J.H. Microtechnology-Based Multi-Organ Models. Bioengineering 2017, 4, 46.

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