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Bioengineering 2017, 4(1), 8; doi:10.3390/bioengineering4010008

Vasculature-On-A-Chip for In Vitro Disease Models

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Received: 29 November 2016 / Revised: 17 January 2017 / Accepted: 19 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
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Abstract

Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularization process so that in vitro recapitulation of vascularization is possible. The current microfluidic systems allow elaborative research on the effects of various cues for vascularization, and furthermore, in vitro technologies have a great potential for being applied to the vascular disease models for studying pathological events and developing drug screening platforms. Here, we review methods of fabrication for microfluidic assays and inducing factors for vascularization. We also discuss applications using engineered vasculature such as in vitro vascular disease models, vasculature in organ-on-chips and drug screening platforms. View Full-Text
Keywords: vasculature-on-a-chip; angiogenesis; microfluidics; in vitro disease models vasculature-on-a-chip; angiogenesis; microfluidics; in vitro disease models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, S.; Kim, W.; Lim, S.; Jeon, J.S. Vasculature-On-A-Chip for In Vitro Disease Models. Bioengineering 2017, 4, 8.

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