Next Article in Journal
Macroscopic Dynamic Modeling of Sequential Batch Cultures of Hybridoma Cells: An Experimental Validation
Previous Article in Journal
Biosynthesis of Inorganic Nanoparticles: A Fresh Look at the Control of Shape, Size and Composition
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle
Bioengineering 2017, 4(1), 16; doi:10.3390/bioengineering4010016

An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment

CNRS, LEMTA, UMR 7563, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54502 Vandoeuvre-lès-Nancy, France
*
Author to whom correspondence should be addressed.
Academic Editor: Gou-Jen Wang
Received: 23 November 2016 / Revised: 6 February 2017 / Accepted: 20 February 2017 / Published: 22 February 2017
View Full-Text   |   Download PDF [2243 KB, uploaded 22 February 2017]   |  

Abstract

Cells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In the present paper, we formulate the hypothesis that the cells orientate in the direction of unitary stretch computed from the right Cauchy-Green tensor in a given mechanical environment. The implications of this hypothesis are studied in different simple cases corresponding to either the available in vitro experimental data or physiological conditions, starting from finite element analysis results to computed preferential cellular orientation. The present contribution is a first step to the formulation of a deeper understanding of the orientation of cells within or at the surface of any 3D scaffold subject to any complex load. It is believed that these initial preferential directions have strong implications as far as the anisotropy of biological structures is concerned. View Full-Text
Keywords: mechanobiology; cell mechanics; mechanosensing; scaffold; numerical simulation mechanobiology; cell mechanics; mechanosensing; scaffold; numerical simulation
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Laurent, C.P.; Ganghoffer, J.-F.; Rahouadj, R. An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment. Bioengineering 2017, 4, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top