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Medicines 2016, 3(3), 24; doi:10.3390/medicines3030024

Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis

1
Biological Product Lab, Department of Botany, University of Allahabad, Allahabad 211002, India
2
Lichenology Laboratory, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226001, India
*
Author to whom correspondence should be addressed.
Academic Editor: James D. Adams
Received: 2 May 2016 / Revised: 15 July 2016 / Accepted: 1 September 2016 / Published: 12 September 2016
(This article belongs to the Special Issue Plant Medicines for Clinical Trial)
View Full-Text   |   Download PDF [566 KB, uploaded 12 September 2016]   |  

Abstract

In the present study, the new biological sources in the form of lichen Usnea orientalis Motyka was screened for its antidermatophytic potential. Six species of dermatophytes were chosen on the basis of their prevalence for antidermatophytic assays, and the Clinical Laboratory Standard Institute (CLSI)-recommended broth microdilution procedure was used to detect the efficacy of extract against dermatophytes. Thin layer chromatography of lichen extracts reveals the presence of two secondary metabolites viz. salazinic acid and usnic acid. U. orientalis extract exhibited promising antidermatophytic activity against all tested pathogens. Amongst all tested pathogens, Epidermophyton floccosum exhibited most susceptibility towards extract, whereas Trichophyton mentagrophytes exhibited the least susceptibility. Topical application of U. orientalis extract might be helpful in the cure of dermal infections. View Full-Text
Keywords: antidermatophytic; dermatophytes; DPPH; Lichen antidermatophytic; dermatophytes; DPPH; Lichen
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Pathak, A.; Upreti, D.K.; Dikshit, A. Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis. Medicines 2016, 3, 24.

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